Label-free sensitive detection of MUC1 using a liquid crystal based-system
DC Field | Value | Language |
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dc.contributor.author | Duong, Thai Duong Song | - |
dc.contributor.author | Jang, Chang-Hyun | - |
dc.date.available | 2020-04-06T07:39:01Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0267-8292 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26454 | - |
dc.description.abstract | This study reports the development of a novel label-free aptasensor which uses the orientation properties of nematic liquid crystals (LCs) to detect mucin 1 (MUC1) is developed. The sensor is made of immobilised amine-functionalised aptamers on the surface, with LCs serving as response elements. When MUC1 interacts with the immobilised aptamers, it forms a complex that disrupts the LC orientation, taking them from homeotropic to random alignment. This change in the orientation of LCs is easily observed as a shift in the optical LC image from dark to bright using a polarised light microscope. This sensing system is highly sensitive (detection limit of 5 fg mL(-1)) and exhibits good specificity for detection of MUC1 without labelling or an additional amplification step. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | LIQUID CRYSTALS | - |
dc.title | Label-free sensitive detection of MUC1 using a liquid crystal based-system | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000514563400001 | - |
dc.identifier.doi | 10.1080/02678292.2020.1729426 | - |
dc.identifier.bibliographicCitation | LIQUID CRYSTALS, v.47, no.12, pp.1784 - 1793 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85079732071 | - |
dc.citation.endPage | 1793 | - |
dc.citation.startPage | 1784 | - |
dc.citation.title | LIQUID CRYSTALS | - |
dc.citation.volume | 47 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Duong, Thai Duong Song | - |
dc.contributor.affiliatedAuthor | Jang, Chang-Hyun | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | Liquid crystal (LC) | - |
dc.subject.keywordAuthor | 4-cyano-4MODIFIER LETTER PRIME-pentylbiphenyl (5CB) | - |
dc.subject.keywordAuthor | mucin 1 (MUC1) | - |
dc.subject.keywordAuthor | aptamer | - |
dc.subject.keywordPlus | TUMOR-MARKER | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | APTASENSOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordPlus | APTAMERS | - |
dc.subject.keywordPlus | ANTIGENS | - |
dc.subject.keywordPlus | TARGET | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Crystallography | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Crystallography | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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