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Pulsatility of middle cerebral arteries is better correlated with white matter hyperintensities than aortic stiffening

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dc.contributor.author이상화-
dc.contributor.author김예림-
dc.contributor.author이영배-
dc.contributor.author이주헌-
dc.date.available2020-04-06T07:41:41Z-
dc.date.created2020-04-02-
dc.date.issued2018-07-
dc.identifier.issn2508-691X-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26543-
dc.description.abstractBackground: Pulsatility of cerebral arteries and aortic stiffness have been associated with white matter hyperintensities (WMH). We explored which is better correlated with the severity of WMH in a population with acute lacunar infarct. Methods: We included patients with acute small subcortical infarcts who underwent transcranial Doppler (TCD) and brachial ankle pulse wave velocity (baPWV). Exclusion criteria were any stenosis or occlusion on major cerebral arteries on magnetic resonance angiography; poor temporal insonation windows; ankle brachial index < 0.9; and atrial fibrillation. We assessed the performance of the pulsatility index of bilateral middle cerebral arteries (PI-MCA) and baPWV for predicting moderate- to-severe WMH, defined as an Age Related White Matter Changes score > 5, and then sought to find independent predictors using binary logistic regression analysis. Results: Eighty-three patients (56 males, mean age 61.5 ± 11.4) participated in the study. Univariate analysis showed old age and high PI-MCA were significantly correlated with moderate- to-severe WMH. However, baPWV was not associated with the severity of WMH. Multivariate analysis revealed old age (odds ratio per 1-year increase, 1.068; p = 0.044) and upper tertile of PI-MCA (odds ratio, 5.138; p = 0.049) were independently associated with moderate-to-severe WMH. Receiver-operating characteristics showed PI-MCA differentiated those with and without moderate-to-severe WMH with an area under the curve of 0.719. Conclusions: PI-MCA derived from TCD was better correlated with the severity of WMH than baPWV in a population with lacunar infarction. Pulsatility of cerebral arteries may better predict cerebral small vessel disease than the aortic stiffness index.-
dc.language영어-
dc.language.isoen-
dc.publisher대한임상신경생리학회-
dc.relation.isPartOfAnnals of Clinical Neurophysiology-
dc.titlePulsatility of middle cerebral arteries is better correlated with white matter hyperintensities than aortic stiffening-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass2-
dc.identifier.doi10.14253/acn.2018.20.2.79-
dc.identifier.bibliographicCitationAnnals of Clinical Neurophysiology, v.20, no.2, pp.79 - 84-
dc.identifier.kciidART002370259-
dc.description.isOpenAccessN-
dc.citation.endPage84-
dc.citation.startPage79-
dc.citation.titleAnnals of Clinical Neurophysiology-
dc.citation.volume20-
dc.citation.number2-
dc.contributor.affiliatedAuthor이영배-
dc.subject.keywordAuthorPulsatility index-
dc.subject.keywordAuthorAortic stiffness-
dc.subject.keywordAuthorTranscranial Doppler ultrasonography-
dc.description.journalRegisteredClasskci-
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