Knockout Mouse Models for Peroxiredoxins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young Jae | - |
dc.date.available | 2020-04-16T07:35:28Z | - |
dc.date.created | 2020-04-14 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/27314 | - |
dc.description.abstract | Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as cellular protection against ROS, inflammation, carcinogenesis, atherosclerosis, heart diseases, and metabolism. In mammals, six PRDX members have been identified and are subdivided into three subfamilies: typical 2-Cys (PRDX1, PRDX2, PRDX3, and PRDX4), atypical 2-Cys (PRDX5), and 1-Cys (PRDX6) subfamilies. Knockout mouse models of PRDXs have been developed to investigate their in vivo roles. This review presents an overview of the knockout mouse models of PRDXs with emphases on the biological and physiological changes of these model mice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.title | Knockout Mouse Models for Peroxiredoxins | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000519877100002 | - |
dc.identifier.doi | 10.3390/antiox9020182 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.9, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85100857301 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Lee, Young Jae | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | peroxiredoxin | - |
dc.subject.keywordAuthor | peroxides | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | knockout mouse | - |
dc.subject.keywordAuthor | animal model | - |
dc.subject.keywordPlus | LENS EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | II PRX-II | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ANTIOXIDANT ENZYME | - |
dc.subject.keywordPlus | IMPAIRED HOMEOSTASIS | - |
dc.subject.keywordPlus | PROTECTIVE ROLE | - |
dc.subject.keywordPlus | CRUCIAL ROLE | - |
dc.subject.keywordPlus | LUNG INJURY | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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