Synthesis and Biological Evaluation of PF-543 Derivative
DC Field | Value | Language |
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dc.contributor.author | Kim, Seon Woong | - |
dc.contributor.author | Lee, Taeho | - |
dc.contributor.author | Lee, Joo-Youn | - |
dc.contributor.author | Kim, Sanghee | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.contributor.author | Park, Eun-Young | - |
dc.contributor.author | Baek, Dong Jae | - |
dc.date.available | 2020-02-27T07:42:41Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1570-1786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2847 | - |
dc.description.abstract | PF-543 has been known as a substance that strongly inhibits SK1. However, it also exhibits antineoplastic activity that is lower than other inhibitors of SK1. In this study, we compared PF-543 and synthesized a newly designed derivative of PF-543 (compound 2) in which two aromatic structures were connected in para-form. The synthesized derivative showed inhibitory effect on SK1, similar to that of PF-543. However, it was more cytotoxic to HT29, AGS, and PC3 cells than PF-543. We also carried out a docking study for SK1 and demonstrated that the synthesized derivative showed interaction with SK1 similar to PF-543. Results obtained from this study suggest that the structure of compound 2 may be well substituted for the structure of PF-543 in terms of biological activity, providing us important structural information for the design of new derivatives of PF-543. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.relation.isPartOf | LETTERS IN ORGANIC CHEMISTRY | - |
dc.title | Synthesis and Biological Evaluation of PF-543 Derivative | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000458300000002 | - |
dc.identifier.doi | 10.2174/1570178615666181009121430 | - |
dc.identifier.bibliographicCitation | LETTERS IN ORGANIC CHEMISTRY, v.16, no.1, pp.2 - 5 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85064902337 | - |
dc.citation.endPage | 5 | - |
dc.citation.startPage | 2 | - |
dc.citation.title | LETTERS IN ORGANIC CHEMISTRY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | PF-543 | - |
dc.subject.keywordAuthor | sphingosine kinase | - |
dc.subject.keywordAuthor | inhibitor | - |
dc.subject.keywordAuthor | anticancer | - |
dc.subject.keywordAuthor | derivative | - |
dc.subject.keywordAuthor | medicinal chemistry | - |
dc.subject.keywordPlus | SPHINGOSINE KINASE 1 | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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