Immobilization of Protein A on Monodisperse Magnetic Nanoparticles for Biomedical Applications
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bui Trung Thanh | - |
dc.contributor.author | Nguyen Van Sau | - |
dc.contributor.author | Ju, Heongkyu | - |
dc.contributor.author | Bashir, Mohammed J. K. | - |
dc.contributor.author | Jun, Hieng Kiat | - |
dc.contributor.author | Thang Bach Phan | - |
dc.contributor.author | Quang Minh Ngo | - |
dc.contributor.author | Ngoc Quyen Tran | - |
dc.contributor.author | Tran Hoang Hai | - |
dc.contributor.author | Pham Hung Van | - |
dc.contributor.author | Tan Tai Nguyen | - |
dc.date.available | 2020-02-27T07:42:51Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1687-4110 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2866 | - |
dc.description.abstract | We presented synthesis and physical characterization of iron oxide magnetic nanoparticles (Fe3O4) for biomedical applications in the size range of 10-30nm. Magnetic nanoparticles were synthesized by the coprecipitation method, and the particles' size was controlled by two different injection methods of sodium hydroxide (NaOH). The synthesized magnetic nanoparticles were then modified by using series of linkers including tetraethyl orthosilicate (TEOS), 3-aminopropyltriethoxysilane (APTES), and glutaraldehyde (GA) to generate the structure of Fe3O4/SiO2/NH2/CHO, which can be used for immobilization of protein A. Additionally, we used transmission electron microscopy (TEM), X-ray powder diffraction (XRD), vibrating-sample magnetometry (VSM), and Fourier-transform infrared spectroscopy (FTIR), for characterization of properties and structure of the nanoparticles. An immobilization of protein A on magnetic nanoparticles was studied with a UV-Vis spectrum (UV-Vis) and fluorescence electron microscopy and Bradford method. Results showed that an XRD spectrum with a peak at (311) corresponded to the standard peak of magnetic nanoparticles. In addition, the magnetic nanoparticles with d >= 30 nm have higher saturation magnetizations in comparison with the smaller ones with d >= 10 nm. However, the smaller magnetic nanoparticles offered higher efficiency for binding of protein A, due to the high surface/volume ratio. These particles with functional groups on their surface are promising candidates for biomedical applications, e.g., drug delivery, controlled drug release, or disease diagnosis in point-of-care test. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | JOURNAL OF NANOMATERIALS | - |
dc.title | Immobilization of Protein A on Monodisperse Magnetic Nanoparticles for Biomedical Applications | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000464793200001 | - |
dc.identifier.doi | 10.1155/2019/2182471 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOMATERIALS, v.2019 | - |
dc.identifier.scopusid | 2-s2.0-85064380239 | - |
dc.citation.title | JOURNAL OF NANOMATERIALS | - |
dc.citation.volume | 2019 | - |
dc.contributor.affiliatedAuthor | Ju, Heongkyu | - |
dc.type.docType | Article | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.