A Multidomain Intervention for Modifying Lifestyle Habits Reduces the Dementia Risk in Community-Dwelling Older Adults: A Single-Blinded Randomized Controlled Pilot Study
DC Field | Value | Language |
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dc.contributor.author | Park, Jee Eun | - |
dc.contributor.author | Jeon, So Yeon | - |
dc.contributor.author | Kim, Se An | - |
dc.contributor.author | Kim, Jin Ha | - |
dc.contributor.author | Kim, Seon Hwa | - |
dc.contributor.author | Lee, Kyung Won | - |
dc.contributor.author | Hwang, Yun Jung | - |
dc.contributor.author | Jung, Gijung | - |
dc.contributor.author | Suk, Hye Won | - |
dc.contributor.author | Park, Saejong | - |
dc.contributor.author | Lee, Dong Young | - |
dc.date.available | 2020-02-27T07:43:01Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2885 | - |
dc.description.abstract | We aimed to examine the feasibility and effectiveness of a multidomain intervention including intensive and maintenance programs for reducing the risk of dementia in at-risk older adults. Community-dwelling older adults (aged >= 60 years) without dementia but having several risk factors for dementia (N = 32; 89% female; mean age f standard deviation, 76.8 +/- 4.7 years) were assigned to three parallel programs: intensive plus maintenance (INT+MNT), intensive only (INTonly), and active control. Subjects in INT+MNT and INT-only groups participated in a 4-week intensive group-based lifestyle modification program that focused on physical activity, vascular risk factors, dietary habits, cognitive activities, and social engagement. INT+MNT participants underwent an additional 20-week maintenance program to consolidate modified habits. The modified Australian National University-Alzheimer's Disease Risk Index (ANU-ADRI) score was used as the primary outcome measure for dementia risk. The changes in ANU-ADRI scores exhibited a significant group-by-time interaction: the INT+MNT group showed significant improvement at 24 weeks beta = -6.05; SE = 1.86; p= 0.002), while the INT-only group did not. Additional exploratory analyses showed that the reduction in ANU-ADRI scores was caused by changes in protective factors rather than in risk factors. The INT + MNT group also showed greater improvement in executive function at 4 and 24 weeks (both p = 0.044), whereas changes in global cognitive function did not reach significance (p = 0.055). A 24-week multidomain dementia prevention involving a maintenance strategy for sustaining modified lifestyle habits reduced the risk of dementia and improved executive function in at-risk older adults. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | KOREAN VERSION | - |
dc.subject | PERFORMANCE | - |
dc.subject | PREVENTION | - |
dc.subject | PEDOMETERS | - |
dc.subject | COLOR | - |
dc.subject | WORD | - |
dc.subject | AGE | - |
dc.title | A Multidomain Intervention for Modifying Lifestyle Habits Reduces the Dementia Risk in Community-Dwelling Older Adults: A Single-Blinded Randomized Controlled Pilot Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000473652200006 | - |
dc.identifier.doi | 10.3233/JAD-190016 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, v.70, no.1, pp.51 - 60 | - |
dc.identifier.scopusid | 2-s2.0-85068554032 | - |
dc.citation.endPage | 60 | - |
dc.citation.startPage | 51 | - |
dc.citation.title | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.volume | 70 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kim, Se An | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Aged | - |
dc.subject.keywordAuthor | alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | dementia | - |
dc.subject.keywordAuthor | health promotion | - |
dc.subject.keywordAuthor | risk reduction behavior | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PEDOMETERS | - |
dc.subject.keywordPlus | COLOR | - |
dc.subject.keywordPlus | WORD | - |
dc.subject.keywordPlus | AGE | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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