Single-Session versus Multisession Gamma Knife Radiosurgery for Large Brain Metastases from Non-Small Cell Lung Cancer: A Retrospective Analysis
DC Field | Value | Language |
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dc.contributor.author | Park, Kawngwoo | - |
dc.contributor.author | Kim, Jin Wook | - |
dc.contributor.author | Chung, Hyun-Tai | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.date.available | 2020-02-27T07:43:08Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1011-6125 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2899 | - |
dc.description.abstract | Purpose: To evaluate the efficacy of Gamma Knife radiosurgery (GKS) in patients with large brain metastases by comparing single-session radiosurgery (S-GKS) and multisession radiosurgery (M-GKS), we retrospectively analyzed the clinical outcomes of patients who underwent GKS for brain metastases from non-small cell lung cancer (NSCLC). Materials and Methods: Between January 2010 and December 2016, 66 patients with 74 lesions >= 10 cm(3) from large brain metastases from only NSCLC were included. Fifty-five patients with 60 lesions were treated with S-GKS; 11 patients with 14 lesions were treated with M-GKS. Median doses were 16 Gy (range, 11-18 Gy) for the S-GKS group and 8 Gy (range, 7-10 Gy) in three fractions for the M-GKS group. Results: With a mean follow-up period of 13.1 months (range, 1.3-76.4 months), the median survival duration was 21.1 months for all patients. Median tumor volume was 14.3 cm(3) (range, 10.0-58.3 cm(3)). The local control rate was 77.0% and the progression-free survival rate was 73.6% at the last follow-up. There were no significant between-group differences in terms of local control rate (p = 0.10). Compared with S-GKS, M-GKS did not differ significantly in radiation-induced complications (38.1 vs. 45.4%, p = 0.83). While 8 patients who underwent S-GKS experienced major complications of grade >= 3, no toxicity was observed in patients treated with M-GKS. Conclusions: M-GKS may be an effective alternative for large brain metastases from NSCLC. Specifically, severe radiation-induced toxicity (>= grade 3) did not occur in M-GKS for large-volume metastases. Although the long-term effects and results from larger samples remain unclear, M-GKS may be a suitable palliative treatment for preserving neurological function. (C) 2019 S. Karger AG, Basel | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.relation.isPartOf | STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | - |
dc.subject | STEREOTACTIC RADIOSURGERY | - |
dc.subject | LOCAL-CONTROL | - |
dc.subject | SURGERY | - |
dc.subject | RADIOTHERAPY | - |
dc.title | Single-Session versus Multisession Gamma Knife Radiosurgery for Large Brain Metastases from Non-Small Cell Lung Cancer: A Retrospective Analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000481459200003 | - |
dc.identifier.doi | 10.1159/000496154 | - |
dc.identifier.bibliographicCitation | STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, v.97, no.2, pp.94 - 100 | - |
dc.identifier.scopusid | 2-s2.0-85066739773 | - |
dc.citation.endPage | 100 | - |
dc.citation.startPage | 94 | - |
dc.citation.title | STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | - |
dc.citation.volume | 97 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Kawngwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gamma Knife radiosurgery | - |
dc.subject.keywordAuthor | Multisession | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.subject.keywordAuthor | Brain metastasis | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
dc.subject.keywordPlus | STEREOTACTIC RADIOSURGERY | - |
dc.subject.keywordPlus | LOCAL-CONTROL | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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