Daratumumab plus bortezomib, melphalan, and prednisone in East Asian patients with non-transplant multiple myeloma: subanalysis of the randomized phase 3 ALCYONE trial
- Authors
- Fujisaki, Tomoaki; Ishikawa, Takayuki; Takamatsu, Hiroyuki; Suzuki, Kenshi; Min, Chang-Ki; Lee, Jae Hoon; Wang, Jianping; Carson, Robin; Crist, Wendy; Qi, Ming; Nagafuji, Koji
- Issue Date
- Dec-2019
- Publisher
- SPRINGER
- Keywords
- Multiple myeloma; Daratumumab; VMP; Transplant-ineligible
- Citation
- ANNALS OF HEMATOLOGY, v.98, no.12, pp.2805 - 2814
- Journal Title
- ANNALS OF HEMATOLOGY
- Volume
- 98
- Number
- 12
- Start Page
- 2805
- End Page
- 2814
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2939
- DOI
- 10.1007/s00277-019-03794-9
- ISSN
- 0939-5555
- Abstract
- In the ALCYONE trial, daratumumab plus bortezomib, melphalan, and prednisone (D-VMP) reduced the risk of disease progression or death by 50% versus bortezomib, melphalan, and prednisone (VMP) in patients with transplant-ineligible newly diagnosed multiple myeloma. Here, we report a subanalysis of East Asian patients from ALCYONE. After a median follow-up of 17.1 and 15.9 months for Japanese (n = 50) and Korean (n = 41) patients, respectively, median progression-free survival for D-VMP versus VMP was not reached (NR) versus 20.7 months in Japanese patients and NR versus 14.0 months in Korean patients. The overall response rate for D-VMP versus VMP was 96% versus 92% in Japanese patients and 91% versus 61% in Korean patients. Using next-generation sequencing, minimal residual disease negativity at 10(-5) sensitivity for D-VMP versus VMP was 33% versus 8% among Japanese patients and 17% versus 0% among Korean patients. Rates of any grade and grade 3/4 pneumonia were consistent with the rates observed for the global safety population. Similar efficacy and safety findings were observed in the combined Japanese and Korean subgroup and >= 75 years of age subgroup. In conclusion, D-VMP was safe and efficacious in East Asian patients, consistent with the global ALCYONE population.
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