Immunogenicity and safety of a tetanus-diphtheria vaccine and a 13-valent pneumococcal conjugate vaccine after concomitant vaccination in >= 50-year-old adults
DC Field | Value | Language |
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dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Cheong, Hee Jin | - |
dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Choi, Min Joo | - |
dc.contributor.author | Yoon, Jin Gu | - |
dc.contributor.author | Lee, Saem Na | - |
dc.contributor.author | Kang, Seong Hui | - |
dc.contributor.author | Jeong, Eun Joo | - |
dc.contributor.author | Jo, Yu Mi | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.date.available | 2020-02-27T08:40:56Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-12-05 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2956 | - |
dc.description.abstract | Background: When two or more vaccines are administered concurrently, there is concern about safety and immunogenicity from vaccine interaction. Methods: Subjects aged >= 50 years were randomized 1: 1: 1 to receive tetanus-diphtheria (Td) + 13-valent pneumococcal conjugate vaccine (PCV13; Group 1), PCV13 alone (Group 2), or Td alone (Group 3). After single or concomitant vaccination, enzyme-linked immunosorbent assay and opsonophagocytic assay (OPA) were performed to compare immunogenicity for Td and PCV13, respectively. Results: A total of 448 subjects were available for the assessment. After concomitant administration, the non-inferiority criteria of geometric mean titer (GMT) ratios were met for tetanus, diphtheria, and all four pneumococcal serotypes (1, 5, 18C, and 19A). However, subjects in Group 3 (Td alone) were more likely to have a high IgG anti-tetanus antibody titer (>= 0.5 U/mL) than those in Group 1 (Td+PCV13) (p<0.01). As for the pneumococcal serotype 1, the OPA GMT was significantly higher in Group 1 (PCV13 + Td) compared to Group 2 (PCV13 alone) (p = 0.02). No serious adverse event occurred. Conclusions: Concomitant Td and PCV13 administration induced sufficient immunity without significant interference and showed good safety profiles. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | BMC INFECTIOUS DISEASES | - |
dc.subject | INFLUENZA VACCINE | - |
dc.subject | GLYCOCONJUGATE VACCINES | - |
dc.subject | ANTIBODY-RESPONSES | - |
dc.subject | CARRIER PROTEIN | - |
dc.subject | IMMUNITY | - |
dc.subject | TRIAL | - |
dc.title | Immunogenicity and safety of a tetanus-diphtheria vaccine and a 13-valent pneumococcal conjugate vaccine after concomitant vaccination in >= 50-year-old adults | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000452275300006 | - |
dc.identifier.doi | 10.1186/s12879-018-3479-9 | - |
dc.identifier.bibliographicCitation | BMC INFECTIOUS DISEASES, v.18 | - |
dc.identifier.scopusid | 2-s2.0-85058505634 | - |
dc.citation.title | BMC INFECTIOUS DISEASES | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Jo, Yu Mi | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Pneumococcal conjugate vaccine | - |
dc.subject.keywordAuthor | Tetanus | - |
dc.subject.keywordAuthor | Diphtheria | - |
dc.subject.keywordAuthor | Immunogenicity | - |
dc.subject.keywordPlus | INFLUENZA VACCINE | - |
dc.subject.keywordPlus | GLYCOCONJUGATE VACCINES | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | CARRIER PROTEIN | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | TRIAL | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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