Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives
DC Field | Value | Language |
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dc.contributor.author | Lee, Ho-Jae | - |
dc.contributor.author | Han, Young-Min | - |
dc.contributor.author | An, Jeong Min | - |
dc.contributor.author | Kang, Eun A. | - |
dc.contributor.author | Park, Yong Jin | - |
dc.contributor.author | Cha, Ji-Young | - |
dc.contributor.author | Hahm, Ki Baik | - |
dc.date.available | 2020-02-27T08:41:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-12-02 | - |
dc.identifier.issn | 1473-7140 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2970 | - |
dc.description.abstract | Introduction: Although inflammation is defensive and healing process that maintains organ homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs abundant in Western diet, are precursors of pro-inflammatory mediators, whereas n-3 PUFAs possess anti-inflammatory properties. Therefore, interest in the cancer-preventive effect of n-3 PUFAs is increasing. Areas covered: We have observed significant reductions of gastrointestinal tumorigenesis in the Fat-1 transgenic mouse as evidenced that the decrease in Helicobacter pylori-infected gastric tumorigenesis, colon, biliary, and pancreatic cancer was seen in Fat-1 mice producing n-3 PUFAs. However, despite many studies showing benefits, evidence-based medicine regarding molecular pathology, epidemiology, and clinical achievement of cancer prevention of n-3 PUFAs are still limited. Expert commentary: Primary deficiency of eicosapentaenoic acids and docosahexaenoic acids in Western diets can explain the risk of cancer development and the importance of n-3/n-6 PUFA ratio in reducing cancer risk. Alteration of cell membrane composition during carcinogenesis is particularly important, due to increased rate of lipid/cholesterol synthesis in cancerous tissues. Here, we discuss that direct incorporation of n-3 PUFAs in the cell membrane corrects abnormal cellular proliferation and decreases inflammation-associated carcinogenesis. This is exemplified by cancer-preventive effects of n-3 PUFAs as fat sources for gastrointestinal cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | EXPERT REVIEW OF ANTICANCER THERAPY | - |
dc.subject | ENGINEERED MOUSE MODELS | - |
dc.subject | FAT-1 TRANSGENIC MICE | - |
dc.subject | BREAST-CANCER | - |
dc.subject | DOCOSAHEXAENOIC ACID | - |
dc.subject | PANCREATIC-CANCER | - |
dc.subject | COLORECTAL-CANCER | - |
dc.subject | COLON-CANCER | - |
dc.subject | N-3 PUFA | - |
dc.subject | FISH-OIL | - |
dc.subject | EICOSAPENTAENOIC ACID | - |
dc.title | Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000450563700004 | - |
dc.identifier.doi | 10.1080/14737140.2018.1524299 | - |
dc.identifier.bibliographicCitation | EXPERT REVIEW OF ANTICANCER THERAPY, v.18, no.12, pp.1189 - 1203 | - |
dc.identifier.scopusid | 2-s2.0-85056392015 | - |
dc.citation.endPage | 1203 | - |
dc.citation.startPage | 1189 | - |
dc.citation.title | EXPERT REVIEW OF ANTICANCER THERAPY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Ho-Jae | - |
dc.contributor.affiliatedAuthor | Cha, Ji-Young | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | n-3 PUFA | - |
dc.subject.keywordAuthor | Fat-1 tg mice | - |
dc.subject.keywordAuthor | cancer prevention | - |
dc.subject.keywordAuthor | anticancer effect | - |
dc.subject.keywordAuthor | gastrointestinal cancer | - |
dc.subject.keywordPlus | ENGINEERED MOUSE MODELS | - |
dc.subject.keywordPlus | FAT-1 TRANSGENIC MICE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | N-3 PUFA | - |
dc.subject.keywordPlus | FISH-OIL | - |
dc.subject.keywordPlus | EICOSAPENTAENOIC ACID | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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