Proton Transfer Accounting for Anomalous Collision-Induced Dissociation of Proton-Bound Hoogsteen Base Pair of Cytosine and Guanine
DC Field | Value | Language |
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dc.contributor.author | Park, Jeong Ju | - |
dc.contributor.author | Lee, Choong Sik | - |
dc.contributor.author | Han, Sang Yun | - |
dc.date.available | 2020-02-27T08:41:19Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1044-0305 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3003 | - |
dc.description.abstract | To understand the anomalous collision-induced dissociation (CID) behavior of the proton-bound Hoogsteen base pair of cytosine (C) and guanine (G), C:H+center dot center dot center dot G, we investigated CID of a homologue series of proton-bound heterodimers of C, 1-methylcytosine, and 5-methylcytosine with G as a common base partner. The CID experiments were performed in an energy-resolved way (ER-CID) under both multiple and near-single collision conditions. The relative stabilities of the protonated complexes examined by ER-CID suggested that the proton-bound complexes produced by electrospray ionization in this study are proton-bound Hoogsteen base pairs. On the other hand, in contrast to the other base pairs, CID of C:H+center dot center dot center dot G exhibited more abundant productions of C:H+, the fragment protonated on the moiety with a smaller proton affinity, than that of G:H+. This appeared to contradict general prediction based on the kinetic method. However, further theoretical exploration of potential energy surfaces found that there can be facile proton transfers in the proton-bound Hoogsteen base pairs during the CID process, which makes the process accessible to an additional product state of O-protonated C for C:H+ fragments. The presence of an additional dissociation channel, which in other words corresponds to twofold degeneracy in the transition state leading to C:H+ fragments, effectively doubles the apparent reaction rate for production of C:H+. In this way, the process gives rise to the anomaly, the observed pronounced formation of C:H+ in the CID of the proton-bound Hoogsteen base pair, C:H+center dot center dot center dot G. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | - |
dc.subject | TANDEM MASS-SPECTROMETRY | - |
dc.subject | GUIDED ION-BEAM | - |
dc.subject | GLYCOSIDIC BOND-CLEAVAGE | - |
dc.subject | COMPREHENSIVE EVALUATION | - |
dc.subject | PYRIMIDINE NUCLEOSIDES | - |
dc.subject | IRMPD SPECTROSCOPY | - |
dc.subject | KINETIC METHOD | - |
dc.subject | DNA-STRUCTURE | - |
dc.subject | ENERGIES | - |
dc.subject | STABILITY | - |
dc.title | Proton Transfer Accounting for Anomalous Collision-Induced Dissociation of Proton-Bound Hoogsteen Base Pair of Cytosine and Guanine | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000450942400010 | - |
dc.identifier.doi | 10.1007/s13361-018-2060-5 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, v.29, no.12, pp.2368 - 2379 | - |
dc.identifier.scopusid | 2-s2.0-85056959061 | - |
dc.citation.endPage | 2379 | - |
dc.citation.startPage | 2368 | - |
dc.citation.title | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Park, Jeong Ju | - |
dc.contributor.affiliatedAuthor | Han, Sang Yun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Proton-bound Hoogsteen base pairs | - |
dc.subject.keywordAuthor | Energy-resolved collision-induced dissociation (ER-CID) | - |
dc.subject.keywordAuthor | Guanine | - |
dc.subject.keywordAuthor | Cytosine | - |
dc.subject.keywordAuthor | Proton transfer | - |
dc.subject.keywordPlus | TANDEM MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | GUIDED ION-BEAM | - |
dc.subject.keywordPlus | GLYCOSIDIC BOND-CLEAVAGE | - |
dc.subject.keywordPlus | COMPREHENSIVE EVALUATION | - |
dc.subject.keywordPlus | PYRIMIDINE NUCLEOSIDES | - |
dc.subject.keywordPlus | IRMPD SPECTROSCOPY | - |
dc.subject.keywordPlus | KINETIC METHOD | - |
dc.subject.keywordPlus | DNA-STRUCTURE | - |
dc.subject.keywordPlus | ENERGIES | - |
dc.subject.keywordPlus | STABILITY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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