Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets
DC Field | Value | Language |
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dc.contributor.author | Kim, S. S. | - |
dc.contributor.author | Jang, H. J. | - |
dc.contributor.author | Oh, M. Y. | - |
dc.contributor.author | Lee, J. H. | - |
dc.contributor.author | Kang, K. S. | - |
dc.date.available | 2020-02-27T08:42:21Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3122 | - |
dc.description.abstract | Background. The transplantation of isolated pancreatic islets is a promising treatment for diabetes. Curcumin has been used for its pharmacologic effects, such as antidiabetic and anti-inflammatory activities. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, has been reported to have antioxidant and anti-inflammatory activities. This study examines the hypothesis that preoperative THC treatment can attenuate ischemic damage and apoptosis before islet transplantation. Methods. Islets isolated from Balb/c mice were randomly divided into 2 groups and cultured in medium supplemented with or without THC. In vitro islet viability and function were assessed. After treatment with a cytokine cocktail consisting of tumor necrosis factor-alpha, interferon-beta, and interleukin-1 beta, islet cell viability, function, and apoptotic status were determined. Proteins related to apoptosis were analyzed using INS-1 cell after streptozocin treatment. Results. There was no difference in cell viability between the 2 groups. Islets cultured in the medium supplemented with THC showed 1.3-fold higher glucose-induced insulin secretion than the islets cultured in the medium without THC. After treatment with a cytokine cocktail, glucose-induced insulin release, and NO of the islets were significantly improved in THC-treated islets compared with islets not treated with THC. Apoptosis was significantly decreased, and B-cell lymphoma-2 was elevated in the THC-treated group. The streptozocin-treated INS-1 cell produced significantly higher levels of and B-cell lymphoma-2-associated X protein, caspase-3, and caspase-9 than INS-1 treated with THC. Conclusions. These results suggest that preoperative THC administration enhances islet function before transplantation and attenuates the cytokine-induced damage associated with apoptosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.subject | TRANSPLANTED ISLETS | - |
dc.subject | INSULIN-SECRETION | - |
dc.subject | CURCUMIN | - |
dc.subject | RAT | - |
dc.subject | EXPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | CULTURE | - |
dc.subject | STRESS | - |
dc.subject | BAX | - |
dc.title | Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000451108800060 | - |
dc.identifier.doi | 10.1016/j.transproceed.2018.03.033 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, v.50, no.9, pp.2847 - 2853 | - |
dc.identifier.scopusid | 2-s2.0-85055881686 | - |
dc.citation.endPage | 2853 | - |
dc.citation.startPage | 2847 | - |
dc.citation.title | TRANSPLANTATION PROCEEDINGS | - |
dc.citation.volume | 50 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Lee, J. H. | - |
dc.contributor.affiliatedAuthor | Kang, K. S. | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | TRANSPLANTED ISLETS | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | BAX | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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