Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation
DC Field | Value | Language |
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dc.contributor.author | Shrestha, Jitendra | - |
dc.contributor.author | Ki, Sung Hwan | - |
dc.contributor.author | Shin, Sang Mi | - |
dc.contributor.author | Kim, Seon Woong | - |
dc.contributor.author | Lee, Joo-Youn | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.contributor.author | Lee, Taeho | - |
dc.contributor.author | Kim, Sanghee | - |
dc.contributor.author | Baek, Dong Jae | - |
dc.contributor.author | Park, Eun-Young | - |
dc.date.available | 2020-02-27T08:42:25Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3132 | - |
dc.description.abstract | FTY720 inhibits various cancers through PP2A activation. The structure of FTY720 is also used as a basic structure for the design of sphingosine kinase (SK) inhibitors. We have synthesized derivatives using an amide chain in FTY720 with a phenyl backbone, and then compounds were screened by an MTT cell viability assay. The PP2A activity of compound 7 was examined. The phosphorylation levels of AKT and ERK, downstream targets of PP2A, in the presence of compound 7, were determined. Compound 7 may exhibit anticancer effects through PP2A activation rather than the mechanism by inhibition of SK1 in cancer cells. In the docking study of compound 7 and PP2A, the amide chain of compound 7 showed an interaction with Asn61 that was different from FTY720, which is expected to affect the activity of the compound. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.subject | CANCER | - |
dc.subject | VINYLPHOSPHONATE | - |
dc.title | Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000451641900022 | - |
dc.identifier.doi | 10.3390/molecules23112750 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.23, no.11 | - |
dc.identifier.scopusid | 2-s2.0-85055462494 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | FTY720 | - |
dc.subject.keywordAuthor | protein phosphatase 2A | - |
dc.subject.keywordAuthor | sphingosine kinase | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | derivative | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | VINYLPHOSPHONATE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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