Natalenamides A-C, Cyclic Tripeptides from the Termite-Associated Actinomadura sp RB99
DC Field | Value | Language |
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dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Benndorf, Rene | - |
dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Lee, Dong-Soo | - |
dc.contributor.author | Huh, Jungmoo | - |
dc.contributor.author | de Beer, Z. Wilhelm | - |
dc.contributor.author | Kim, Yong Ho | - |
dc.contributor.author | Beemelmanns, Christine | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-27T08:42:27Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3134 | - |
dc.description.abstract | In recent years, investigations into the biochemistry of insect-associated bacteria have increased. When combined with analytical dereplication processes, these studies provide a powerful strategy to identify structurally and/or biologically novel compounds. Non-ribosomally synthesized cyclic peptides have a broad bioactivity spectrum with high medicinal potential. Here, we report the discovery of three new cyclic tripeptides: natalenamides A-C (compounds 1-3). These compounds were identified from the culture broth of the fungus-growing termite-associated Actinomadura sp. RB99 using a liquid chromatography (LC)/ultraviolet (UV)/mass spectrometry (MS)-based dereplication method. Chemical structures of the new compounds (1-3) were established by analysis of comprehensive spectroscopic methods, including one-dimensional (H-1 and C-13) and two-dimensional (H-1-H-1-COSY, HSQC, HMBC) nuclear magnetic resonance spectroscopy (NMR), together with high-resolution electrospray ionization mass spectrometry (HR-ESIMS) data. The absolute configurations of the new compounds were elucidated using Marfey's analysis. Through several bioactivity tests for the tripeptides, we found that compound 3 exhibited significant inhibitory effects on 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production. The effect of compound 3 was similar to that of kojic acid, a compound extensively used as a cosmetic material with a skin-whitening effect. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | INHIBITORS | - |
dc.subject | SYMBIONTS | - |
dc.subject | DNA | - |
dc.title | Natalenamides A-C, Cyclic Tripeptides from the Termite-Associated Actinomadura sp RB99 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000451641900275 | - |
dc.identifier.doi | 10.3390/molecules23113003 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.23, no.11 | - |
dc.identifier.scopusid | 2-s2.0-85056613073 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Soo | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | fungus-growing termite | - |
dc.subject.keywordAuthor | Actinomadura sp. | - |
dc.subject.keywordAuthor | tripeptides | - |
dc.subject.keywordAuthor | natalenamides A-C | - |
dc.subject.keywordAuthor | skin-whitening effects | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | SYMBIONTS | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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