Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis
DC Field | Value | Language |
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dc.contributor.author | Kwon, Ha-Kyoung | - |
dc.contributor.author | Song, Min-Jung | - |
dc.contributor.author | Lee, Hye-Ji | - |
dc.contributor.author | Park, Tae-Sik | - |
dc.contributor.author | Kim, Moon Il | - |
dc.contributor.author | Park, Hye-Jin | - |
dc.date.available | 2020-02-27T08:42:36Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3152 | - |
dc.description.abstract | Cordyceps militaris is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of C. militaris grown on germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The total polyphenol content (TPC) and total flavonoid content (TFC) in the GRC-ON89A ethanol extract were significantly increased compared to that in GRC. GRC-ON89A hexane fraction (GRC-ON89A-Hex) inhibited the release of nitric oxide (NO) compared to that of the LPS-treated control without cytotoxicity in LPS-stimulated RAW 264.7 macrophages. GRC-ON89A-Hex decreased the inducible NO synthase (iNOS), cyclooxygenase 2 (COX2), and tumor necrosis factor (TNF)- mRNA expression in LPS-stimulated RAW 264.7 macrophages. In addition, pre-treatment with GRC-ON89A-Hex significantly inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-B. To induce allergic contact dermatitis (ACD), 1-fluoro-2, 4-dinitrofluorobenzene (DNFB) was applied to the surface of the right ears of C57BL/6N mice. GRC-ON89A reduced the ear swelling and thickness in DNFB-induced ACD mice. This study demonstrates the potential usefulness of GRC-ON89A as an anti-inflammatory dietary supplement or drug. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | GERMINATED BROWN RICE | - |
dc.subject | RAW 264.7 MACROPHAGES | - |
dc.subject | CHLAMYDOMONAS-REINHARDTII | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | ALPHA EXPRESSION | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | TNF-ALPHA | - |
dc.subject | CELLS | - |
dc.subject | ADENOSINE | - |
dc.title | Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000451528500220 | - |
dc.identifier.doi | 10.3390/ijms19113504 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.11 | - |
dc.identifier.scopusid | 2-s2.0-85056414270 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kwon, Ha-Kyoung | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Ji | - |
dc.contributor.affiliatedAuthor | Park, Tae-Sik | - |
dc.contributor.affiliatedAuthor | Kim, Moon Il | - |
dc.contributor.affiliatedAuthor | Park, Hye-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | GRC-ON89A | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | DNFB-induced ACD mice | - |
dc.subject.keywordAuthor | NF-B | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | GERMINATED BROWN RICE | - |
dc.subject.keywordPlus | RAW 264.7 MACROPHAGES | - |
dc.subject.keywordPlus | CHLAMYDOMONAS-REINHARDTII | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | ALPHA EXPRESSION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ADENOSINE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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