Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis: a Korean multicenter study
DC Field | Value | Language |
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dc.contributor.author | Park, Yong Eun | - |
dc.contributor.author | Cheon, Jae Hee | - |
dc.contributor.author | Park, Jae Jun | - |
dc.contributor.author | Kim, Yoon Jae | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.contributor.author | Park, Yehyun | - |
dc.contributor.author | Park, Soo Jung | - |
dc.contributor.author | Kim, Tae Il | - |
dc.contributor.author | Kim, Won Ho | - |
dc.date.available | 2020-02-27T09:40:39Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0179-1958 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3231 | - |
dc.description.abstract | Background Primary sclerosing cholangitis (PSC) is a rare progressive cholestatic liver disease of unknown causes, but is strongly associated with inflammatory bowel diseases (IBDs), particularly ulcerative colitis (UC). However, studies comparing risk factors and clinical courses of patients with concomitant UC and PSC with those of patients with PSC alone are lacking. Methods We retrospectively reviewed patients with PSC diagnosed between 2005 and 2017 in four tertiary hospitals in Korea. We compared the risk factors and outcomes of concomitant UC and PSC (UC-PSC) and those of PSC alone. Results PSC was diagnosed in 50 patients in four different tertiary hospitals in Korea. Of them, 18 patients (36.0%) had UC-PSC and 32 patients (64.0%) had PSC alone. The median age at PSC diagnosis was younger in the UC-PSC group than that in the PSC alone group (37 vs. 54 years, P=0.002). In multivariate analysis, older age at PSC diagnosis (P=0.007; odds ratio [OR], 0.884; 95% confidence interval [CI], 0.808-0.966) and current smoking habit (P=0.033; OR, 0.026; 95% CI, 0.001-0.748) were determined to be independent factors for reducing the possibility of developing concomitant UC after PSC. Additionally, UCPSC was shown to be an independent risk factor for the development of colorectal dysplasia (P=0.044; OR, 10.829; 95% CI, 1.065-110.127). Conclusions Our analysis showed that UC-PSC is more likely to be negatively associated with current smoking and older age at the time of PSC diagnosis. Moreover, UC-PSC increased the risk of colorectal dysplasia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | - |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject | PREVALENCE | - |
dc.title | Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis: a Korean multicenter study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000444736000023 | - |
dc.identifier.doi | 10.1007/s00384-018-3123-6 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, v.33, no.10, pp.1497 - 1500 | - |
dc.identifier.scopusid | 2-s2.0-85049623108 | - |
dc.citation.endPage | 1500 | - |
dc.citation.startPage | 1497 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Primary sclerosing cholangitis | - |
dc.subject.keywordAuthor | Ulcerative colitis | - |
dc.subject.keywordAuthor | inflammatory bowel disease | - |
dc.subject.keywordAuthor | Risk factor | - |
dc.subject.keywordAuthor | Outcome assessment | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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