Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model
DC Field | Value | Language |
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dc.contributor.author | Chun, Eunho | - |
dc.contributor.author | Yoon, Soojung | - |
dc.contributor.author | Parveen, Amna | - |
dc.contributor.author | Jin, Mirim | - |
dc.date.available | 2020-02-27T09:40:52Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3257 | - |
dc.description.abstract | Irritable bowel syndrome (IBS) is a common gastrointestinal disorder manifesting as unexplained abdominal pain and bowel habit changes. The pathogenesis of post-infectious IBS is associated with gut-brain axis dysfunction, including low-grade colonic inflammation and anxiety-related long-term brain changes. This study analyzed the efficacy of a standardized extract of Dolichos lablab L. extract (DL), a bean species, in an IBS mouse model resembling post-infectious, diarrhea-dominant IBS. Using a zymosan-induced animal IBS model, we found that oral administration of DL significantly attenuated zymosan-induced increases in colonic macroscopic scores and minimized weight loss without affecting food intake. In the DL-treated mice, the mast cell count and tumor necrosis factor-alpha level in the colon markedly decreased, similar to results in sulfasalazine-treated mice and in mice with lipopolysaccharide-stimulated bone marrow-derived mast cells. The number of visceral pain-related behaviors was much lower in the DL-treated mice. Anxiety-like behaviors significantly improved, comparable to that after treatment with amitriptyline. The c-Fos expression level in the prefrontal cortex was significantly reduced. Our data suggest that DL could be beneficial for treating IBS by acting on the gut and brain. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.subject | FUNCTIONAL GASTROINTESTINAL DISORDERS | - |
dc.subject | MAST-CELLS | - |
dc.subject | MECHANISMS | - |
dc.subject | HYPERALGESIA | - |
dc.subject | METAANALYSIS | - |
dc.subject | DEPRESSION | - |
dc.subject | STRESS | - |
dc.subject | PAIN | - |
dc.subject | RAT | - |
dc.subject | IBS | - |
dc.title | Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000448821300141 | - |
dc.identifier.doi | 10.3390/nu10101475 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.10, no.10 | - |
dc.identifier.scopusid | 2-s2.0-85054755354 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Chun, Eunho | - |
dc.contributor.affiliatedAuthor | Yoon, Soojung | - |
dc.contributor.affiliatedAuthor | Parveen, Amna | - |
dc.contributor.affiliatedAuthor | Jin, Mirim | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | irritable bowel syndrome | - |
dc.subject.keywordAuthor | Dolichos lablab L. | - |
dc.subject.keywordAuthor | zymosan-induced IBS | - |
dc.subject.keywordAuthor | mouse model | - |
dc.subject.keywordAuthor | gut-brain axis | - |
dc.subject.keywordAuthor | colonic inflammation | - |
dc.subject.keywordAuthor | pain | - |
dc.subject.keywordAuthor | anxiety | - |
dc.subject.keywordPlus | FUNCTIONAL GASTROINTESTINAL DISORDERS | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | IBS | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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