Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for Si-29 Magnetic Resonance Imaging
DC Field | Value | Language |
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dc.contributor.author | Seo, Hyeonglim | - |
dc.contributor.author | Choi, Ikjang | - |
dc.contributor.author | Whiting, Nicholas | - |
dc.contributor.author | Hu, Jingzhe | - |
dc.contributor.author | Luu, Quy Son | - |
dc.contributor.author | Pudakalakatti, Shivanand | - |
dc.contributor.author | McCowan, Caitlin | - |
dc.contributor.author | Kim, Yaewon | - |
dc.contributor.author | Zacharias, Niki | - |
dc.contributor.author | Lee, Seunghyun | - |
dc.contributor.author | Bhattacharya, Pratip | - |
dc.contributor.author | Lee, Youngbok | - |
dc.date.available | 2020-02-27T09:41:22Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-09-05 | - |
dc.identifier.issn | 1439-4235 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3319 | - |
dc.description.abstract | Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for Si-29 magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their Si-29 MR signals; the particles demonstrated long Si-29 spin-lattice relaxation (T-1) times (approximate to 25mins), which suggests potential applicability for medical imaging. Furthermore, Si-29 hyperpolarization levels were sufficient to allow Si-29 MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes invivo. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | CHEMPHYSCHEM | - |
dc.subject | SIZE | - |
dc.subject | REDUCTION | - |
dc.subject | PARTICLES | - |
dc.subject | T-1 | - |
dc.title | Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for Si-29 Magnetic Resonance Imaging | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000443680500005 | - |
dc.identifier.doi | 10.1002/cphc.201800461 | - |
dc.identifier.bibliographicCitation | CHEMPHYSCHEM, v.19, no.17, pp.2143 - 2147 | - |
dc.identifier.scopusid | 2-s2.0-85052784335 | - |
dc.citation.endPage | 2147 | - |
dc.citation.startPage | 2143 | - |
dc.citation.title | CHEMPHYSCHEM | - |
dc.citation.volume | 19 | - |
dc.citation.number | 17 | - |
dc.contributor.affiliatedAuthor | Lee, Seunghyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | porous silicon nanoparticles | - |
dc.subject.keywordAuthor | DNP | - |
dc.subject.keywordAuthor | molecular magnetic resonance imaging | - |
dc.subject.keywordAuthor | theragnostic material | - |
dc.subject.keywordAuthor | Si-29 hyperpolarization | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | T-1 | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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