Hyaluronic acid-coated cisplatin conjugated gold nanoparticles for combined cancer treatment

Abstract

Gold nanoparticles are widely utilized for medical applications such as drug carriers and therapeutic and diagnostic agents due to their small size and great surface area. In the present study, we prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles to selectively deliver cisplatin into a tumor, and obtain synergistic effects using laser treatment. Our prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles were found to have a mean hydrodynamic diameter of approximately 140 nm and negative surface charge. The nanoparticles showed greater cytotoxicity than free cisplatin and in vivo antitumor efficacy in tumor models when near infra-red laser was applied. Therefore, this formulation could be applied for combined cancer therapy. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.