Sensitive and selective method for detecting cysteine based on optical properties of liquid crystal
- Authors
- Au, Zongfu; Jang, Chang-Hyun
- Issue Date
- 15-Sep-2018
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- Cysteine; Biosurfactant; Liquid crystals (LCs); 4-Cyano-4 ' -pentylbiphenyl (5CB)
- Citation
- SENSORS AND ACTUATORS B-CHEMICAL, v.269, pp.135 - 142
- Journal Title
- SENSORS AND ACTUATORS B-CHEMICAL
- Volume
- 269
- Start Page
- 135
- End Page
- 142
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3337
- DOI
- 10.1016/j.snb.2018.04.168
- ISSN
- 0925-4005
- Abstract
- We demonstrate a novel strategy to detect cysteine using a liquid crystal (LC) biosensor at an aqueous interface. We synthesized a novel biosurfactant, which was effectively exploited to design an optical biosensor based on treated LC. Lauroyl-doped 5CB was used as a cysteine indicator based on the reaction between lauroyl chloride and cysteine at the aqueous/LC interface. Following the reaction, the orientation of LCs succeeded in a four-petal shape, as observed using a polarizing optical microscope where the optical signals received (as derived from the LCs orientation changes) were attributed to the newly formed biosurfactant. Additionally, the prepared biosensor has a LOD (limit of detection) of cysteine at the picomolar level (pM), better than that LOD which can be achieved by conventional methods These results suggest that use of a LC biosensor is an appropriate approach for cysteine detection, particularly for sensing low levels of cysteine in biological environments. (C) 2018 Elsevier B.V. All rights reserved.
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