Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line
DC Field | Value | Language |
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dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Song, Ji Hoon | - |
dc.contributor.author | Song, Jae-Hyoung | - |
dc.contributor.author | Ko, Hyun-Jeong | - |
dc.contributor.author | Baek, Ji Yun | - |
dc.contributor.author | Tuy An Trinh | - |
dc.contributor.author | Beemelmanns, Christine | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-27T09:42:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3426 | - |
dc.description.abstract | Insect-associated bacteria have been recognized as a very promising natural resource for discovering bioactive secondary metabolites with diverse pharmacological effects. One new isoflavonoid glycoside, termisoflavone D (1), together with seven known isoflavonoids (2-8), were identified from MeOH extracts of the fungus-growing termite-associated Streptomyces sp. RB1. The chemical structure of the new compound 1 was elucidated using comprehensive spectroscopic methods including 1D and 2D NMR, along with LC/MS analysis. The existence of two rhamnose moieties in 1 was determined with comparative NMR analysis, and the absolute configuration was elucidated using chemical reactions. The neuroprotective activities of compounds 1-8 were thoroughly investigated using the murine hippocampal HT22 cell line. Compound 5 prevented glutamate-induced HT22 cell death by blocking intracellular reactive oxygen species (ROS) accumulation. The present study provides the first experimental evidence for the potential use of isoflavonoids from termite-associated bacteria as lead compounds that can prevent neuronal damage induced by glutamate. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | MECHANISMS | - |
dc.subject | GLYCOSIDES | - |
dc.subject | PEPTIDE | - |
dc.title | Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000449988100176 | - |
dc.identifier.doi | 10.3390/ijms19092640 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.9 | - |
dc.identifier.scopusid | 2-s2.0-85053085913 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Baek, Ji Yun | - |
dc.contributor.affiliatedAuthor | Tuy An Trinh | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | fungus-growing termite | - |
dc.subject.keywordAuthor | Streptomyces sp. | - |
dc.subject.keywordAuthor | isoflavonoid | - |
dc.subject.keywordAuthor | neuroprotective effect | - |
dc.subject.keywordAuthor | glutamate | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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