Dual action of the G alpha(q)-PLC beta-PI(4,5) P-2 pathway on TRPC1/4 and TRPC1/5 heterotetramers
DC Field | Value | Language |
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dc.contributor.author | Myeong, Jongyun | - |
dc.contributor.author | Ko, Juyeon | - |
dc.contributor.author | Kwak, Misun | - |
dc.contributor.author | Kim, Jinsung | - |
dc.contributor.author | Woo, Joohan | - |
dc.contributor.author | Ha, Kotdaji | - |
dc.contributor.author | Hong, Chansik | - |
dc.contributor.author | Yang, Dongki | - |
dc.contributor.author | Kim, Hyun Jin | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.contributor.author | So, Insuk | - |
dc.date.available | 2020-02-27T09:42:34Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-08-14 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3485 | - |
dc.description.abstract | The transient receptor potential canonical (TRPC)1 channel is widely distributed in mammalian cells and is involved in many physiological processes. TRPC1 is primarily considered a regulatory subunit that forms heterotetrameric channels with either TRPC4 or TRPC5 subunits. Here, we suggest that the regulation of TRPC1/4 and TRPC1/5 heterotetrameric channels by the G alpha(q)-PLCO pathway is self-limited and dynamically mediated by G alpha(q) and PI(4,5)P-2. We provide evidence indicating that Gag protein directly interacts with eitherTRPC4 or TRPC5 of the heterotetrameric channels to permit activation. Simultaneously, G alpha(q)-coupled PLCO activation leads to the breakdown of PI(4,5)P-2, which inhibits activity of TRPC1/4 and 1/5 channels. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | PHOSPHOLIPASE-C | - |
dc.subject | CA2+ CHANNELS | - |
dc.subject | ACTIVATION | - |
dc.subject | DIACYLGLYCEROL | - |
dc.subject | IDENTIFICATION | - |
dc.subject | PI(4,5)P-2 | - |
dc.subject | MODULATION | - |
dc.subject | CALMODULIN | - |
dc.subject | ALPHA | - |
dc.subject | PIP2 | - |
dc.title | Dual action of the G alpha(q)-PLC beta-PI(4,5) P-2 pathway on TRPC1/4 and TRPC1/5 heterotetramers | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000441538200010 | - |
dc.identifier.doi | 10.1038/s41598-018-30625-0 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.identifier.scopusid | 2-s2.0-85053409035 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Yang, Dongki | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | CA2+ CHANNELS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DIACYLGLYCEROL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PI(4,5)P-2 | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | CALMODULIN | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | PIP2 | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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