Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung Won | - |
dc.contributor.author | Hong, Ji Yeon | - |
dc.contributor.author | Bae, Seung Min | - |
dc.date.available | 2020-02-27T09:42:42Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1738-1088 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3501 | - |
dc.description.abstract | Autism spectrum disorder is a rapidly increasing heterogeneous neurodevelopmental syndrome, remarked by persistent deficit in social communication, and restricted, repetitive patterns of behavior and interest. Lately, maternal immune activation and micgroglial dysfunction in the developing brain have been gaining mounting evidence and leading to studies of various novel agents as potential treatment options. A few immunomodulatory treatment options-luteolin, minocycline, suramin, vitamin D, gut microbiota-are discussed in the current article, regarding the current understanding of their mechanisms and evidence for potential clinical use. More studies are warranted to understand their exact mechanisms of action and to verify efficacy and safety in human subjects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN COLL NEUROPSYCHOPHARMACOLOGY | - |
dc.relation.isPartOf | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.title | Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000440733000002 | - |
dc.identifier.doi | 10.9758/cpn.2018.16.3.246 | - |
dc.identifier.bibliographicCitation | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.16, no.3, pp.246 - 252 | - |
dc.identifier.kciid | ART002376269 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85051394514 | - |
dc.citation.endPage | 252 | - |
dc.citation.startPage | 246 | - |
dc.citation.title | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Bae, Seung Min | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Autism spectrum disorder | - |
dc.subject.keywordAuthor | Maternal immune activation | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Immunomodulatory therapy | - |
dc.subject.keywordPlus | MATERNAL IMMUNE ACTIVATION | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INCREASED PREVALENCE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MINOCYCLINE | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | LUTEOLIN | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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