Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy
DC Field | Value | Language |
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dc.contributor.author | So, Hae Min | - |
dc.contributor.author | Eom, Hee Jeong | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Sil | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Il Kyun | - |
dc.contributor.author | Baek, Kwan-Hyuck | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-27T10:40:47Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3544 | - |
dc.description.abstract | Identification of bioactive natural products with anticancer activity as well as alleviating effects on chemotherapy-induced side effects has significant implications for cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has been used in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B. platyphylla var. japonica bark, and betulin was isolated from EtOH extract using an LC/MS-guided isolation method. Its structure was identified with H-1 and C-13 NMR spectroscopic data and LC/MS analysis and then compared to the previously reported spectroscopic and physical data. We first verified the cytotoxicity of betulin against three human lung adenocarcinoma cell lines, A549, H1264, and Calu-6, with IC50 values ranging from 18.7 to 39.6 mu M. Regarding alleviation of side effects associated with anticancer chemotherapy, betulin ameliorated cisplatin-induced renal cell damage to 80% of the control value from the concentration of 5 mu M. In addition, betulin showed anti-gastritis activity against ethanol-induced gastric damage in rats and notably reduced the gastric damage index compared to control in a concentration-dependent manner. These findings provide the first experimental evidence for potential use of B. platyphylla var. japonica as a functional food for cancer treatment that simultaneously alleviates the side effects of chemotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | PERIPHERAL NEUROPATHY | - |
dc.subject | CISPLATIN | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | EXTRACT | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | GLYCOSIDES | - |
dc.subject | GASTRITIS | - |
dc.subject | EFFICACY | - |
dc.subject | STRESS | - |
dc.title | Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000443448800003 | - |
dc.identifier.doi | 10.1007/s12272-018-1064-9 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.41, no.8, pp.815 - 822 | - |
dc.identifier.kciid | ART002378153 | - |
dc.identifier.scopusid | 2-s2.0-85051430149 | - |
dc.citation.endPage | 822 | - |
dc.citation.startPage | 815 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 41 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Betula platyphylla var. japonica | - |
dc.subject.keywordAuthor | Betulin | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Nephrotoxicity | - |
dc.subject.keywordAuthor | Anti-gastritis | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | PERIPHERAL NEUROPATHY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | GASTRITIS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | STRESS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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