Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Ji Hye | - |
dc.contributor.author | Jung, Hyo Won | - |
dc.contributor.author | Kang, Seok Yong | - |
dc.contributor.author | Kang, An Na | - |
dc.contributor.author | Ma, Jun Nan | - |
dc.contributor.author | Meng, Xiang Long | - |
dc.contributor.author | Hwang, Min Sub | - |
dc.contributor.author | Park, Yong-Ki | - |
dc.date.available | 2020-02-27T10:41:09Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 1792-0981 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3591 | - |
dc.description.abstract | Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced in Sprague-Dawley rats by subcutaneous injection of Propylthiouracil (PTU; 10 mg/kg) once daily for 4 weeks. MOK was administered by acupuncture on the acupoints around the thyroid gland of PTU-induced hypothyroidism rats once daily for 2 weeks following hypothyroidism induction. Administration of MOK pharmacopuncture significantly increased the PTU-induced decrease in body temperature of hypothyroidism rats. The weights of the spleen were also significantly decreased in hyperthyroidism rats following MOK pharmacopuncture. MOK pharmacopuncture significantly decreased the thyroid stimulating hormone level and increased the T3 and T4 levels in hypothyroidism rats. Administration of MOK pharmacopuncture significantly increased the glucose levels and decreased the levels of triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and alanine transaminase in the sera of hypothyroidism rats. The expression of transient receptor potential cation channel subfamily V member 1 was increased in dorsal root ganglion and brain tissues by administration of MOK pharmacopuncture, and glutathione levels and the expression of superoxide dismutase 1 and catalase were increased in the liver and brain tissues. Administration of MOK pharmacopuncture significantly inhibited interferon-gamma expression and increased the expression of interleukin (IL)-4, IL-10, and Forkhead Box P3 in the spleen tissues of hypothyroidism rats. In histological analysis, the administration of MOK pharmacopuncture improved the pathological features in the thyroid glands of hypothyroidism rats. The results suggested that the administration of pharmacopuncture may ameliorate the pathological progression of hypothyroidism by multiple actions, including normalization of the hypothyroidism-induced thyroid hormone imbalance, stimulation of the antioxidant defense system, and regulation of the T helper (Th)1/Th2 imbalance. Therefore, MOK extract may be used for the treatment of hypothyroidism in Korean clinics as a useful pharmacopuncture medicine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.relation.isPartOf | EXPERIMENTAL AND THERAPEUTIC MEDICINE | - |
dc.title | Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000437115500044 | - |
dc.identifier.doi | 10.3892/etm.2018.6190 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND THERAPEUTIC MEDICINE, v.16, no.1, pp.310 - 320 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85047453092 | - |
dc.citation.endPage | 320 | - |
dc.citation.startPage | 310 | - |
dc.citation.title | EXPERIMENTAL AND THERAPEUTIC MEDICINE | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Hwang, Ji Hye | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | acupuncture | - |
dc.subject.keywordAuthor | hypothyroidism | - |
dc.subject.keywordAuthor | MOK | - |
dc.subject.keywordAuthor | pharmacopuncture | - |
dc.subject.keywordAuthor | TRPV1 channel | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | Th1/Th2 balance | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | ANTIOXIDANT DEFENSE SYSTEM | - |
dc.subject.keywordPlus | THYROID-HORMONE REGULATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | HEPATOTOXICITY | - |
dc.subject.keywordPlus | REPLACEMENT | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.