The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)
DC Field | Value | Language |
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dc.contributor.author | Kwon, Jeanny | - |
dc.contributor.author | Eom, Keun-Young | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Chun, Mison | - |
dc.contributor.author | Lee, Jihae | - |
dc.contributor.author | Kim, Yong Bae | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Choi, Jin Hwa | - |
dc.contributor.author | Chang, Sei Kyung | - |
dc.contributor.author | Jeong, Bae Kwon | - |
dc.contributor.author | Lee, Seok Ho | - |
dc.contributor.author | Cha, Jihye | - |
dc.date.available | 2020-02-27T10:41:28Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3633 | - |
dc.description.abstract | Purpose We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define a high-risk group using prognosticators for recurrence. Materials and Methods A multicenter retrospective study was conducted using the data from 13 Korean institutions from 2000 to 2010. A total of 249 IB-IIA patients with high-risk factors were included. We evaluated distant metastasis-free survival (DMFS) and disease-free survival (DFS) in relation to clinicopathologic factors including pN stage, number of mPLN, lymph node (LN) ratio (number of positive LN/number of harvested LN), and log odds of mPLNs (log(number of positive LN+0.5/number of negative LN+0.5)). Results In univariate analysis, histology (squamous cell carcinoma [SqCC] vs. others), lymphovascular invasion (LVI), number of mPLNs (<= 3 vs. > 3), LN ratio (<= 17% vs. > 17%), and log odds of mPLNs (<= -0.58 vs. > -0.58) were significant prognosticators for DMFS and DFS. Resection margin involvement only affected DFS. No significant survival difference was observed between pN0 patients and patients with 1-3 mPLNs. Multivariate analysis revealed that mPLN > 3, LVI, and non-SqCC were unfavorable index for both DMFS (p < 0.001, p=0.020, and p=0.031, respectively) and DFS (p < 0.001, p=0.017, and p=0.001, respectively). A scoring system using these three factors predicts risk of recurrence with relatively high concordance index (DMFS, 0.69; DFS, 0.71). Conclusion mPLN > 3 in early-stage cervical cancer affects DMFS and DFS. A scoring system using mPLNs > 3, LVI, and non-SqCC could stratify risk groups of recurrence in surgically resected early-stage cervix cancer with high-risk factors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.subject | GYNECOLOGIC-ONCOLOGY-GROUP | - |
dc.subject | SQUAMOUS-CELL CARCINOMA | - |
dc.subject | PELVIC RADIATION-THERAPY | - |
dc.subject | RADICAL HYSTERECTOMY | - |
dc.subject | LOG ODDS | - |
dc.subject | SURVIVAL | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | SURGERY | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | RADIOTHERAPY | - |
dc.title | The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000438332100034 | - |
dc.identifier.doi | 10.4143/crt.2017.346 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.50, no.3, pp.964 - 974 | - |
dc.identifier.kciid | ART002366905 | - |
dc.identifier.scopusid | 2-s2.0-85048479772 | - |
dc.citation.endPage | 974 | - |
dc.citation.startPage | 964 | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Seok Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Uterine cervical neoplasms | - |
dc.subject.keywordAuthor | Adjuvant treatment | - |
dc.subject.keywordAuthor | Combined modality therapy | - |
dc.subject.keywordAuthor | Lymphatic metastasis | - |
dc.subject.keywordAuthor | Scoring system | - |
dc.subject.keywordPlus | GYNECOLOGIC-ONCOLOGY-GROUP | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | PELVIC RADIATION-THERAPY | - |
dc.subject.keywordPlus | RADICAL HYSTERECTOMY | - |
dc.subject.keywordPlus | LOG ODDS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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