Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | Song, Na-Young | - |
dc.contributor.author | Lee, Yeon-Hwa | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Baek, Jeong-Heum | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.available | 2020-02-27T10:41:28Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3635 | - |
dc.description.abstract | Leptin, a representative adipokine secreted from the white adipose tissue, is considered as a potential linker between obesity and cancer. SIRT1 is an NAD(+)-dependent histone/protein deacetylase speculated to function as an oncogene. In the present study, we found that leptin signaling-defective ob/ob and db/db mice had lower colonic expression of SIRT1 compared with leptin signaling-intact C57BL/6J mice, implying that leptin signaling is crucial for SIRT1 expression in vivo. Moreover, leptin induced up-regulation of SIRT1 in human colon cancer (HCT-116) cells. Leptin stimulated migration and invasion of cultured HCT-116 cells and tumor growth in the xenograft assay, and these effects were abrogated by a SIRT1 inhibitor sirtinol, suggesting that SIRT1 plays a role in leptin-induced colon carcinogenesis. Leptin-induced SIRT1 expression was regulated by the redox-sensitive transcription factor NF-E2-related factor 2 (Nrf2). Leptin stimulated nuclear accumulation of Nrf2 as well as its binding to the antioxidant response elements located in the SIRT1 promoter. Moreover, siRNA knockdown of Nrf2 abrogated the leptin-induced SIRT1 expression. Notably, SIRT1 was significantly reduced in colon tissues of Nrf2-null mice, lending further support to Nrf2-dependent SIRT1 expression. Expression of leptin, Nrf2 and SIRT1 was coordinately increased in human colon tumor tissues. In conclusion, leptin might play a role in colon carcinogenesis by inducing Nrf2-dependent SIRT1 overexpression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | BREAST-CANCER | - |
dc.subject | CELL-GROWTH | - |
dc.subject | RECEPTOR | - |
dc.subject | PROMOTES | - |
dc.subject | WEIGHT | - |
dc.subject | NRF2 | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | DEACETYLATION | - |
dc.title | Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000434102600026 | - |
dc.identifier.doi | 10.1016/j.bcp.2018.02.001 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.153, pp.282 - 291 | - |
dc.identifier.scopusid | 2-s2.0-85042147011 | - |
dc.citation.endPage | 291 | - |
dc.citation.startPage | 282 | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 153 | - |
dc.contributor.affiliatedAuthor | Baek, Jeong-Heum | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Leptin | - |
dc.subject.keywordAuthor | SIRT1 | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | Obesity-associated cancer | - |
dc.subject.keywordAuthor | Colon carcinogenesis | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CELL-GROWTH | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | WEIGHT | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | DEACETYLATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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