Predicting effective remifentanil concentration in 95% of patients to prevent emergence cough after laryngomicroscopic surgery
DC Field | Value | Language |
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dc.contributor.author | Kim, Ha Yeon | - |
dc.contributor.author | Kim, Jong Yeop | - |
dc.contributor.author | Ahn, Soo Hwan | - |
dc.contributor.author | Lee, Sook Young | - |
dc.contributor.author | Park, Hee Yeon | - |
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.date.available | 2020-02-27T10:42:08Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3721 | - |
dc.description.abstract | Smooth emergence or cough prevention is a clinically important concern in patients undergoing laryngomicroscopic surgery (LMS). The purpose of this study was to estimate the effective concentration of remifentanil in 95% of patients (EC95) for the prevention of emergence cough after LMS under propofol anesthesia using the biased coin design (BCD) up-down method. A total of 40 adult patients scheduled to undergo elective LMS were enrolled. Anesthesia induction and maintenance were performed with target-controlled infusion of propofol and remifentanil. Effective effect-site concentration (Ce) of remifentanil in 95% of patients for preventing emergence cough was estimated using a BCD method (starting from 1 ng/mL with a step size of 0.4 ng/mL). Hemodynamic and recovery profiles were observed after anesthesia. According to the study protocol, 20 patients were allocated to receive remifentanil Ce of 3.0 ng/mL, and 20 patients were assigned to receive lower concentrations of remifentanil, from 1.0 to 2.6 ng/mL. Based on isotonic regression with a bootstrapping method, EC95 (95% CI) of remifentanil Ce for the prevention of emergence cough from LMS was found to be 2.92 ng/mL (2.72-2.97 ng/mL). Compared with patients receiving lower concentrations of remifentanil, the incidence of hypoventilation before extubation and extubation time were significantly higher in those receiving remifentanil Ce of 3.0 ng/mL. However, hypoventilation incidence after extubation and staying time in the recovery room were comparable between the 2 groups. Using a BCD method, the EC95 of remifentanil Ce for the prevention of emergence cough was estimated to be 2.92 ng/mL (95% CI: 2.72-2.97 ng/mL) after LMS under propofol anesthesia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | MEDICINE | - |
dc.subject | EFFECT-SITE CONCENTRATION | - |
dc.subject | GENERAL-ANESTHESIA | - |
dc.subject | ENDOTRACHEAL-TUBE | - |
dc.subject | SMOOTH EMERGENCE | - |
dc.subject | PROPOFOL | - |
dc.subject | SEVOFLURANE | - |
dc.subject | INFUSION | - |
dc.subject | RESPONSES | - |
dc.subject | CHILDREN | - |
dc.subject | DESIGN | - |
dc.title | Predicting effective remifentanil concentration in 95% of patients to prevent emergence cough after laryngomicroscopic surgery | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000439552200058 | - |
dc.identifier.doi | 10.1097/MD.0000000000011258 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.97, no.26 | - |
dc.identifier.scopusid | 2-s2.0-85049413001 | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 97 | - |
dc.citation.number | 26 | - |
dc.contributor.affiliatedAuthor | Park, Hee Yeon | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cough | - |
dc.subject.keywordAuthor | emergence | - |
dc.subject.keywordAuthor | laryngomicroscopic surgery | - |
dc.subject.keywordAuthor | remifentanil | - |
dc.subject.keywordAuthor | target-controlled infusion | - |
dc.subject.keywordPlus | EFFECT-SITE CONCENTRATION | - |
dc.subject.keywordPlus | GENERAL-ANESTHESIA | - |
dc.subject.keywordPlus | ENDOTRACHEAL-TUBE | - |
dc.subject.keywordPlus | SMOOTH EMERGENCE | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.subject.keywordPlus | SEVOFLURANE | - |
dc.subject.keywordPlus | INFUSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | DESIGN | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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