Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
DC Field | Value | Language |
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dc.contributor.author | Kim, Ik-Jung | - |
dc.contributor.author | Lee, Jeongmin | - |
dc.contributor.author | Oh, Seung J. | - |
dc.contributor.author | Yoon, Mee-Sup | - |
dc.contributor.author | Jang, Sung-Soo | - |
dc.contributor.author | Holland, Robin L. | - |
dc.contributor.author | Reno, Michael L. | - |
dc.contributor.author | Hamad, Mohammed N. | - |
dc.contributor.author | Maeda, Tatsuya | - |
dc.contributor.author | Chung, Hee Jung | - |
dc.contributor.author | Chen, Jie | - |
dc.contributor.author | Blanke, Steven R. | - |
dc.date.available | 2020-02-27T10:42:22Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-05-09 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3753 | - |
dc.description.abstract | Helicobacter pylori (Hp) vacuolating cytotoxin (VacA) is a bacterial exotoxin that enters host cells and induces mitochondrial dysfunction. However, the extent to which VacA-dependent mitochondria! perturbations affect overall cellular metabolism is poorly understood. We report that VacA perturbations in mitochondria are linked to alterations in cellular amino acid homeostasis, which results in the inhibition of mammalian target of rapamycin complex 1 (mTORC1) and subsequent autophagy. mTORC1, which regulates cellular metabolism during nutrient stress, is inhibited during Hp infection by a VacA-dependent mechanism. This VacA-dependent inhibition of mTORC1 signaling is linked to the dissociation of mTORC1 from the lysosomal surface and results in activation of cellular autophagy through the Unc 51-like kinase 1 (U1k1) complex. VacA intoxication results in reduced cellular amino acids, and bolstering amino acid pools prevents VacA-mediated mTORC1 inhibition. Overall, these studies support a model that Hp modulate host cell metabolism through the action of VacA at mitochondria. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.subject | GASTRIC EPITHELIAL-CELLS | - |
dc.subject | PYLORI VACUOLATING TOXIN | - |
dc.subject | CYTOCHROME-C RELEASE | - |
dc.subject | AMINO-ACIDS | - |
dc.subject | CYTOTOXIN PRODUCTION | - |
dc.subject | AUTOPHAGY | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | INFECTION | - |
dc.subject | PATHWAY | - |
dc.subject | TARGETS | - |
dc.title | Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000432436400005 | - |
dc.identifier.doi | 10.1016/j.chom.2018.04.006 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, v.23, no.5, pp.583 - + | - |
dc.identifier.scopusid | 2-s2.0-85046747505 | - |
dc.citation.endPage | + | - |
dc.citation.startPage | 583 | - |
dc.citation.title | CELL HOST & MICROBE | - |
dc.citation.volume | 23 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Yoon, Mee-Sup | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | amino acid homeostasis | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | metabolism | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | mitochondrial dysfunction | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | mTORC1 | - |
dc.subject.keywordAuthor | Ulk 1 | - |
dc.subject.keywordAuthor | VacA | - |
dc.subject.keywordAuthor | vacuolating cytotoxin | - |
dc.subject.keywordPlus | GASTRIC EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | PYLORI VACUOLATING TOXIN | - |
dc.subject.keywordPlus | CYTOCHROME-C RELEASE | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | CYTOTOXIN PRODUCTION | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | TARGETS | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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