6,7,4 '-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice
DC Field | Value | Language |
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dc.contributor.author | Ko, Yong-Hyun | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Seok-Yong | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.date.available | 2020-02-27T10:42:22Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-05-05 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3754 | - |
dc.description.abstract | Daidzein is one of the major isoflavfones found in soy food and plants. Following ingestion, daidzein is readily converted to hydroxylated metabolites in the human body. 6,7,4'-Trihydroxyisoflavone (THIF), one of the metabolites of daidzein, has several pharmacological activities, including anti-cancer and anti-obesity properties. However, no reports exist on the effects of 6,7,4'-THIF for cognitive function in mice. The present study aimed to investigate the effects of 6,7,4'-THIF against scopolamine-induced learning and memory impairments using the Y-maze and passive avoidance test. A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests. Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice. In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice. Taken together, these findings suggest that 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.subject | SCOPOLAMINE-INDUCED AMNESIA | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | SPATIAL MEMORY | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | DEFICITS | - |
dc.subject | EXTRACT | - |
dc.subject | BDNF | - |
dc.subject | INHIBITION | - |
dc.title | 6,7,4 '-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000428255000017 | - |
dc.identifier.doi | 10.1016/j.ejphar.2018.02.048 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.826, pp.140 - 147 | - |
dc.identifier.scopusid | 2-s2.0-85043391292 | - |
dc.citation.endPage | 147 | - |
dc.citation.startPage | 140 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 826 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 6,7,4 &apos | - |
dc.subject.keywordAuthor | -Trihydroxyisoflavone | - |
dc.subject.keywordAuthor | Cognition | - |
dc.subject.keywordAuthor | Brain-derived neurotrophic factor | - |
dc.subject.keywordAuthor | cAMP response element binding | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | SCOPOLAMINE-INDUCED AMNESIA | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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