Protective Effect of Artemisia argyi and Its Flavonoid Constituents against Contrast-Induced Cytotoxicity by Iodixanol in LLC-PK1 Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Chang-Eop | - |
dc.contributor.author | Park, Sa-Yoon | - |
dc.contributor.author | Kim, Kem Ok | - |
dc.contributor.author | Hiep, Nguyen Tuan | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Jang, Hyuk-Jai | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T11:40:39Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3833 | - |
dc.description.abstract | Preventive effects and corresponding molecular mechanisms of mugwort (Artemisia argyi) extract and its flavonoid constituents on contrast-induced nephrotoxicity were explored in the present study. We treated cultured LLC-PK1 cells with iodixanol to induce contrast-induced nephrotoxicity, and found that A. argyi extracts ameliorated the reduction in cellular viability following iodixanol treatment. The anti-apoptotic effect of A. argyi extracts on contrast-induced nephrotoxicity was mediated by the inhibition of mitogen-activated protein kinase (MAPK) phosphorylation and the activation of caspases. The flavonoid compounds isolated from A. argyi improved the viability of iodixanol-treated cells against contrast-induced nephrotoxicity. Seven compounds (1, 2, 3, 15, 16, 18, and 19) from 19 flavonoids exerted a significant protective effect. Based on the in silico oral-bioavailability and drug-likeness assessment, which evaluate the drug potential of these compounds, compound 2 (artemetin) showed the highest oral bioavailability (49.55%) and drug-likeness (0.48) values. We further investigated the compound-target-disease network of compound 2, and proliferator-activated receptor gamma (PPAR-gamma) emerged as a predicted key marker for the treatment of contrast-induced nephrotoxicity. Consequently, compound 2 was the preferred candidate, and its protective effect was mediated by inhibiting the contrast-induced inflammatory response through activation of PPAR-gamma and inhibition of MAPK phosphorylation and activation of caspases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | ACUTE KIDNEY INJURY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | ETHANOL EXTRACT | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | IN-VITRO | - |
dc.subject | INDUCED NEPHROPATHY | - |
dc.subject | ASIATICA EXTRACT | - |
dc.title | Protective Effect of Artemisia argyi and Its Flavonoid Constituents against Contrast-Induced Cytotoxicity by Iodixanol in LLC-PK1 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000435297000123 | - |
dc.identifier.doi | 10.3390/ijms19051387 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.5 | - |
dc.identifier.scopusid | 2-s2.0-85046694915 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Eop | - |
dc.contributor.affiliatedAuthor | Park, Sa-Yoon | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | iodixanol | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordAuthor | Artemisia argyi | - |
dc.subject.keywordAuthor | flavonoid | - |
dc.subject.keywordPlus | ACUTE KIDNEY INJURY | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ETHANOL EXTRACT | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INDUCED NEPHROPATHY | - |
dc.subject.keywordPlus | ASIATICA EXTRACT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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