Long-term effects on glycaemic control and beta-cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial
DC Field | Value | Language |
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dc.contributor.author | Chon, Suk | - |
dc.contributor.author | Rhee, Sang Youl | - |
dc.contributor.author | Ahn, Kyu Jeung | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Park, Yongsoo | - |
dc.contributor.author | Nam, Moon Suk | - |
dc.contributor.author | Lee, Kwan Woo | - |
dc.contributor.author | Yoo, Soon Jib | - |
dc.contributor.author | Koh, Gwanpyo | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Kim, Young Seol | - |
dc.contributor.author | Woo, Jeong-Taek | - |
dc.date.available | 2020-02-27T11:40:42Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3840 | - |
dc.description.abstract | Aim: To determine the effects of early intensive glycaemic control with intensive insulin treatment (IIT) or initial combined oral antidiabetic drug (COAD) therapy on long-term glycaemic control and the preservation of beta-cell function in people with type 2 diabetes mellitus (T2DM). Methods: Newly diagnosed drug-naive patients with T2DM from 8 outpatient diabetes centres were randomized to receive either IIT (n=50; glargine/glulisine) or COAD (n=47; glimepiride/ metformin) as intensive treatment until the termination criteria to ensure euglycaemia were met. After intensive treatment, the patients completed a follow-up period with either lifestyle modification (LSM) alone or rescue therapy to maintain target glycated haemoglobin levels of <7% (53 mmol/mol) up to week 104. The primary outcomes were analysed after excluding participants who were anti-glutamic acid decarboxylase autoantibody-positive. Results: Both intensive treatment methods were effective for short-term glycaemic control, but improvements in the disposition index (DI) were significantly greater in the IIT group than in the COAD group (P=.021). During the follow-up period after intensive treatment, the two groups significantly differed in rescue method regarding the maintenance of comparable levels of glycaemic control (P=.010) and more participants who received IIT exhibited well-controlled glycaemia with LSM alone. Additionally, the IIT group maintained a higher DI than the COAD group during the follow-up period. Cox regression analysis showed that the IIT method was associated with a 52.5% lower risk of failing to maintain drug-free glycaemic remission compared with the COAD method (P=.015). Conclusions: The findings indicate that outpatient clinic-based IIT to ensure euglycaemia in newly diagnosed patients with T2DM might be an effective initial therapeutic option for improvements in beta-cell function and glycaemic control over the long term, without serious adverse events. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | DIABETES OBESITY & METABOLISM | - |
dc.subject | DISEASE-MODIFYING THERAPIES | - |
dc.subject | INSULIN THERAPY | - |
dc.subject | PARALLEL-GROUP | - |
dc.subject | FOLLOW-UP | - |
dc.subject | MELLITUS | - |
dc.subject | DYSFUNCTION | - |
dc.subject | PREVALENCE | - |
dc.subject | REMISSION | - |
dc.subject | SECRETION | - |
dc.subject | EFFICACY | - |
dc.title | Long-term effects on glycaemic control and beta-cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000430070000005 | - |
dc.identifier.doi | 10.1111/dom.13196 | - |
dc.identifier.bibliographicCitation | DIABETES OBESITY & METABOLISM, v.20, no.5, pp.1121 - 1130 | - |
dc.identifier.scopusid | 2-s2.0-85040770368 | - |
dc.citation.endPage | 1130 | - |
dc.citation.startPage | 1121 | - |
dc.citation.title | DIABETES OBESITY & METABOLISM | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | blood glucose | - |
dc.subject.keywordAuthor | combination | - |
dc.subject.keywordAuthor | drug therapy | - |
dc.subject.keywordAuthor | glimepiride | - |
dc.subject.keywordAuthor | hyperglycaemia | - |
dc.subject.keywordAuthor | hypoglycaemic agents | - |
dc.subject.keywordAuthor | insulin glargine | - |
dc.subject.keywordAuthor | insulin glulisine | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
dc.subject.keywordPlus | DISEASE-MODIFYING THERAPIES | - |
dc.subject.keywordPlus | INSULIN THERAPY | - |
dc.subject.keywordPlus | PARALLEL-GROUP | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | REMISSION | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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