Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced allergic rhinitis in the mouse
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyeong Ah | - |
dc.contributor.author | Jung, Joo Hyun | - |
dc.contributor.author | Choi, Yun Sook | - |
dc.contributor.author | Kang, Il Gyu | - |
dc.contributor.author | Kim, Seon Tae | - |
dc.date.available | 2020-02-27T11:40:46Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-04-09 | - |
dc.identifier.issn | 2152-6567 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3848 | - |
dc.description.abstract | Background: Wogonin is commonly used for the treatment of allergic diseases. However, neither its precise effect in preventing allergic rhinitis (AR) nor its mechanism of action are known. Objectives: In this study, the effect of wogonin on allergic responses in ovalbumin (OVA) induced AR was investigated in mice. Methods: BALB/c mice were sensitized with intraperitoneal (i.p.) OVA and then challenged intranasally with OVA. Wogonin (10 and 30 mg/kg) was given to the treatment groups, and the effect of wogonin on the release of allergic inflammatory mediators, specifically OVA-specific immunoglobulin E (IgE) and inflammatory cytokines, was explored. Eosinophil infiltration and the levels of interleukin (IL) 5 and IL-13 were measured by immunohistochemistry. Results: In mice with AR, wogonin decreased OVA-specific IgE levels in serum, and the levels of the cytokines IL-4, IL-5, IL-13, eotaxin, and RANTES in nasal lavage fluid. Serum levels of IL-4, IL-5, and IL-13 were lower in both groups of wogonin-pretreated mice than in the OVA group. A reduction in eosinophil infiltration of the nasal mucosa and inhibition of the expression of IL-5 and IL-13 were also noted in the treated groups. Conclusion: Wogonin induced antiallergic effects in a murine model of AR by decreasing the infiltration of eosinophils and levels of T-helper type 2 cytokines. Thus, wogonin merits consideration as a therapeutic agent for treating AR. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.relation.isPartOf | ALLERGY & RHINOLOGY | - |
dc.subject | ASTHMA | - |
dc.subject | EXPRESSION | - |
dc.subject | SCUTELLARIA | - |
dc.subject | DISEASES | - |
dc.subject | HEALTH | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | EOSINOPHILS | - |
dc.subject | CYTOKINES | - |
dc.subject | DIAGNOSIS | - |
dc.subject | BAICALEIN | - |
dc.title | Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced allergic rhinitis in the mouse | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000451456700001 | - |
dc.identifier.doi | 10.1177/2152656718764145 | - |
dc.identifier.bibliographicCitation | ALLERGY & RHINOLOGY, v.9 | - |
dc.citation.title | ALLERGY & RHINOLOGY | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kim, Kyeong Ah | - |
dc.contributor.affiliatedAuthor | Jung, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Yun Sook | - |
dc.contributor.affiliatedAuthor | Kang, Il Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Seon Tae | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SCUTELLARIA | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | EOSINOPHILS | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | BAICALEIN | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
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