Renoprotective Effects of Hypoxylonol C and F Isolated from Hypoxylon truncatum against Cisplatin-Induced Cytotoxicity in LLC-PK1 Cells
DC Field | Value | Language |
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dc.contributor.author | Hwang, Buyng Su | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Choi, Pilju | - |
dc.contributor.author | Kim, Kyu Sun | - |
dc.contributor.author | Choi, Seon-Jun | - |
dc.contributor.author | Song, Bong Geun | - |
dc.contributor.author | Kim, Taejung | - |
dc.contributor.author | Song, Ji Hoon | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Ham, Jungyeob | - |
dc.date.available | 2020-02-27T11:41:20Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3919 | - |
dc.description.abstract | Although cisplatin is the standard platinum-based anticancer drug used to treat various solid tumors, it can cause damage in normal kidney cells. Protective strategies against cisplatin-induced nephrotoxicity are, therefore, clinically important and urgently required. To address this challenge, we investigated the renoprotective effects of Hypoxylon truncatum, a ball-shaped wood-rotting fungus. Chemical investigation of the active fraction from the methanol extract of H. truncatum resulted in the isolation and identification of the renoprotective compounds, hypoxylonol C and F, which ameliorated cisplatin-induced nephrotoxicity to approximately 80% of the control value at 5 mu M. The mechanism of this effect was further investigated using hypoxylonol F, which showed a protective effect at the lowest concentration. Upregulated phosphorylation of p38, extracellular signal-regulated kinases, and c-Jun N-terminal kinases following cisplatin treatment were markedly decreased after pre-treatment with hypoxylonol F. In addition, the protein expression level of cleaved caspase-3 was significantly reduced after co-treatment with hypoxylonol F. These results show that blocking the mitogen-activated protein kinase signaling cascade plays a critical role in mediating the renoprotective effect of hypoxylonol F isolated from H. truncatum fruiting bodies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | PROXIMAL TUBULAR CELLS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | INDUCED NEPHROTOXICITY | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | DEATH | - |
dc.subject | CASPASES | - |
dc.subject | CANCER | - |
dc.title | Renoprotective Effects of Hypoxylonol C and F Isolated from Hypoxylon truncatum against Cisplatin-Induced Cytotoxicity in LLC-PK1 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000434978700027 | - |
dc.identifier.doi | 10.3390/ijms19040948 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.4 | - |
dc.identifier.scopusid | 2-s2.0-85044441472 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Choi, Pilju | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hypoxylon truncatum | - |
dc.subject.keywordAuthor | renoprotective effect | - |
dc.subject.keywordAuthor | hypoxylonol | - |
dc.subject.keywordPlus | PROXIMAL TUBULAR CELLS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | CASPASES | - |
dc.subject.keywordPlus | CANCER | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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