Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells
DC Field | Value | Language |
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dc.contributor.author | Song, Ji Hoon | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Jang, Tae Su | - |
dc.contributor.author | Nam, Joo-Won | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T11:41:22Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3924 | - |
dc.description.abstract | A phytochemical investigation of the MeOH extracts from mulberries (the fruit of Morus alba L.) led to the identification of six heterocyclic compounds (1-6). These compounds were screened to detect whether they protected pancreatic INS-1 cells from streptozotocin (STZ)-induced cytotoxicity. Compound 3 was the most effective at preventing STZ-induced cytotoxicity and the production of reactive oxygen species (ROS) in INS-1 cells. In addition, compound 3 effectively prevented apoptosis induced by STZ in INS-1 cells. Compound 3 also prevented STZ-mediated cleavage of caspase-8, caspase-3 and poly (ADP-ribose) polymerase and increased the expression of B-cell lymphoma-2 (Bcl-2), an anti-apoptotic Bcl-2 family protein. In conclusion, the results of the present study indicate that compound 3 extracted from the fruit of M. alba was highly effective in preventing type 1 diabetes mellitus and may be a novel treatment option. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.relation.isPartOf | MOLECULAR MEDICINE REPORTS | - |
dc.subject | TYPE-2 DIABETES-MELLITUS | - |
dc.subject | MORUS-ALBA L. | - |
dc.subject | HIGH-FAT-DIET | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | BLOOD-GLUCOSE | - |
dc.subject | FRUIT | - |
dc.subject | RATS | - |
dc.subject | POLYSACCHARIDES | - |
dc.subject | FLAVONOIDS | - |
dc.subject | DISEASE | - |
dc.title | Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000428672100142 | - |
dc.identifier.doi | 10.3892/mmr.2018.8582 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.17, no.4, pp.5982 - 5987 | - |
dc.identifier.scopusid | 2-s2.0-85043291634 | - |
dc.citation.endPage | 5987 | - |
dc.citation.startPage | 5982 | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Morus alba | - |
dc.subject.keywordAuthor | streptozotocin | - |
dc.subject.keywordAuthor | type 1 diabetes mellitus | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | MORUS-ALBA L. | - |
dc.subject.keywordPlus | HIGH-FAT-DIET | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BLOOD-GLUCOSE | - |
dc.subject.keywordPlus | FRUIT | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | POLYSACCHARIDES | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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