Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice
DC Field | Value | Language |
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dc.contributor.author | Byeon, Se Eun | - |
dc.contributor.author | Yi, Young-Su | - |
dc.contributor.author | Lee, Jongsung | - |
dc.contributor.author | Yang, Woo Seok | - |
dc.contributor.author | Kim, Ji Hye | - |
dc.contributor.author | Kim, Jooyoung | - |
dc.contributor.author | Hong, Suntaek | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.available | 2020-02-27T11:41:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4003 | - |
dc.description.abstract | Hydroquinone (HQ, 1,4-benzenediol) is a hydroxylated benzene metabolite with various biological activities, including anti-oxidative, neuroprotective, immunomodulatory, and anti-inflammatory functions. However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in vivo anti-cancer activity of HQ was investigated in various cancer cells and tumor-bearing mouse models. HQ significantly induced the death of A431, SYF, B16F10, and MDA-MB-231 cells and also showed a synergistic effect on A431 cell death with other anti-cancer agents, such as adenosine-2',3'-dialdehyde and buthionine sulfoximine. In addition, HQ suppressed angiogenesis in fertilized chicken embryos. Moreover, HQ prevented lung metastasis of melanoma cells in mice in a dose-dependent manner without toxicity and adverse effects. HQ (10 mg/kg) also suppressed the generation of colon and reduced the thickness of colon tissues in azoxymethane/dextran sodium sulfate-injected mice. This study strongly suggests that HQ possesses in vitro and in vivo anti-cancer activity and provides evidence that HQ could be developed as an effective and safe anti-cancer drug. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | BUTHIONINE SULFOXIMINE | - |
dc.subject | REACTIVE METABOLITE | - |
dc.subject | INHIBITION | - |
dc.subject | BENZENE | - |
dc.subject | SRC | - |
dc.subject | AKT | - |
dc.title | Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000428309800260 | - |
dc.identifier.doi | 10.3390/ijms19030903 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.3 | - |
dc.identifier.scopusid | 2-s2.0-85044183480 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Jooyoung | - |
dc.contributor.affiliatedAuthor | Hong, Suntaek | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hydroquinone | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | anti-angiogenesis | - |
dc.subject.keywordAuthor | anti-metastasis | - |
dc.subject.keywordAuthor | anti-tumorigenic response | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | BUTHIONINE SULFOXIMINE | - |
dc.subject.keywordPlus | REACTIVE METABOLITE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BENZENE | - |
dc.subject.keywordPlus | SRC | - |
dc.subject.keywordPlus | AKT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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