Antigastritis effects of Armillariella tabescens (Scop.) Sing. and the identification of its anti-inflammatory metabolites
DC Field | Value | Language |
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dc.contributor.author | Lee, Seulah | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Seok, Soonja | - |
dc.contributor.author | Jang, Tae Su | - |
dc.contributor.author | Park, Hyun Bong | - |
dc.contributor.author | Shim, Sang Hee | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-27T11:42:03Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4022 | - |
dc.description.abstract | ObjectivesThis study demonstrates the biological and chemical analysis of the mushroom Armillariella tabescens (Scop.) Sing. (Tricholomataceae). MethodsChemical structures of the isolates were determined by 1D and 2D NMR, and ESI-MS, as well as comparison with previously reported data. All isolates were tested for anti-inflammatory effects based on their ability to inhibit LPS-stimulated nitric oxide (NO) production in RAW264.7 cells. Key findingsWe found that the MeOH extract of the fruiting bodies of A. tabescens showed antigastritis activity against ethanol-induced gastric damage in rats and notably reduced the gastric damage index compared to control in a concentration-dependent manner. Chemical investigation of the MeOH extract led to the isolation of four steroids (1-4), three alkaloids (5-7), two nucleic acids (8-9) and four fatty acids (10-13). This is the first study to report the identification of all isolates, except for compound 7, from A. tabescens. Compounds 1, 2, 3, 4 and 10 showed inhibition on LPS-stimulated NO production. Treatment with compound 10 inhibited expression of iNOS, COX-2, phospho-IKK, IKK, phospho-IB, IB and NF-kappa B in LPS-stimulated RAW264.7 cells. ConclusionsCompound 10 likely contributes to the health benefits of A. tabescens as an antigastritis agent through its anti-inflammatory effects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | TOLL-LIKE RECEPTOR-4 | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | FRUITING BODIES | - |
dc.subject | INFLAMMATORY RESPONSES | - |
dc.subject | CHEMICAL-CONSTITUENTS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | INHIBITORY-ACTIVITY | - |
dc.subject | HERICIUM-ERINACEUS | - |
dc.subject | RAW264.7 CELLS | - |
dc.title | Antigastritis effects of Armillariella tabescens (Scop.) Sing. and the identification of its anti-inflammatory metabolites | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000425094800011 | - |
dc.identifier.doi | 10.1111/jphp.12871 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACY AND PHARMACOLOGY, v.70, no.3, pp.404 - 412 | - |
dc.identifier.scopusid | 2-s2.0-85042124320 | - |
dc.citation.endPage | 412 | - |
dc.citation.startPage | 404 | - |
dc.citation.title | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.citation.volume | 70 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Park, Jun Yeon | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | antigastritis | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | Armillariella tabescens | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Tricholomataceae | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR-4 | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | FRUITING BODIES | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | CHEMICAL-CONSTITUENTS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | INHIBITORY-ACTIVITY | - |
dc.subject.keywordPlus | HERICIUM-ERINACEUS | - |
dc.subject.keywordPlus | RAW264.7 CELLS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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