Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Se-Ra | - |
dc.contributor.author | Kim, Jae-Wan | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.contributor.author | Roh, Joo Young | - |
dc.contributor.author | Lee, Hwa-Yong | - |
dc.contributor.author | Hong, In-Sun | - |
dc.date.available | 2020-02-27T11:42:12Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02-07 | - |
dc.identifier.issn | 1525-0016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4040 | - |
dc.description.abstract | Stem cells introduced to site of injury primarily act via indirect paracrine effects rather than direct cell replacement of damaged cells. This gives rise to understanding the stem cell secretome. In this study, in vitro studies demonstrate that the secretome activates the PI3K/Akt or FAK/ERK1/2 signaling cascades and subsequently enhances the proliferative and migratory abilities of various types of skin cells, such as fibroblasts, keratinocytes, and vascular epithelial cells, ultimately accelerating wound contraction. Indeed, inhibition of these signaling pathways with synthetic inhibitors resulted in the disruption of secretome-induced beneficial effects on various skin cells. In addition, major components of the stem cell secretome (EGF, basic FGF, and HGF) may be responsible for the acceleration of wound contraction. Stimulatory effects of these three prominent factors on wound contraction are achieved through the upregulation of PI3K/Akt or FAK/ERK1/2 activity. Overall, we lay the rationale for using the stem cell secretome in promoting wound contraction. In vivo wound healing studies are warranted to test the significance of our in vitro findings. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | MOLECULAR THERAPY | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | CONDITIONED MEDIUM | - |
dc.subject | DERMAL FIBROBLAST | - |
dc.subject | BONE-MARROW | - |
dc.subject | CROSS-TALK | - |
dc.subject | SKIN | - |
dc.subject | MIGRATION | - |
dc.subject | KERATINOCYTES | - |
dc.subject | THERAPY | - |
dc.title | Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000425206300025 | - |
dc.identifier.doi | 10.1016/j.ymthe.2017.09.023 | - |
dc.identifier.bibliographicCitation | MOLECULAR THERAPY, v.26, no.2, pp.606 - 617 | - |
dc.identifier.scopusid | 2-s2.0-85031761604 | - |
dc.citation.endPage | 617 | - |
dc.citation.startPage | 606 | - |
dc.citation.title | MOLECULAR THERAPY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Se-Ra | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Wan | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.contributor.affiliatedAuthor | Roh, Joo Young | - |
dc.contributor.affiliatedAuthor | Hong, In-Sun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | paracrine effect | - |
dc.subject.keywordAuthor | stem cell secretome | - |
dc.subject.keywordAuthor | wound healing | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | CONDITIONED MEDIUM | - |
dc.subject.keywordPlus | DERMAL FIBROBLAST | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | CROSS-TALK | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.