Arctigenin protects against ultraviolet-A-induced damage to stemness through inhibition of the NF-kappa B/MAPK pathway
DC Field | Value | Language |
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dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.contributor.author | Oh, Sae Woong | - |
dc.contributor.author | Kang, Mingyeong | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Yoo, Ju Ah | - |
dc.contributor.author | Jung, Kwangseon | - |
dc.contributor.author | Lee, Jienny | - |
dc.contributor.author | Lee, Sang Yeol | - |
dc.contributor.author | Lee, Jongsung | - |
dc.date.available | 2020-02-27T11:42:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02-25 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4049 | - |
dc.description.abstract | The stemness of stem cells is negatively affected by ultraviolet A (UVA) irradiation. This study was performed to examine the effects of arctigenin on UVA-irradiation-induced damage to the stemness of human mesenchymal stem cells (hMSCs) derived from adipose tissue. The mechanisms of action of arctigenin were also investigated. A BrdU-incorporation assay demonstrated that arctigenin attenuated the UVA-induced reduction of the cellular proliferative potential. Arctigenin also increased the UVA-induced reduction in stemness of hMSCs by upregulating stemness-related genes such as SOX2, OCT4, and NANOG. In addition, the UVA-induced reduction in the mRNA expression level of hypoxia-inducible factor (HIF)-1 alpha was significantly recovered by arctigenin. The antagonizing effect of arctigenin on UVA irradiation was mediated by reduced PGE(2) production through the inhibition of MAPKs (p42/44 MAPK, p38 MAPK, and JNK) and NF-kappa B. Overall, these findings suggest that arctigenin can ameliorate the reduced stemness of hMSCs induced by UVA irradiation. The effects of arctigenin are mediated by PGE2-cAMP signaling-dependent upregulation of HIF-1 alpha. Therefore, arctigenin could be used as an antagonist to attenuate the effects of UVA irradiation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.subject | UP-REGULATION | - |
dc.subject | CELLS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | INFLAMMATION | - |
dc.subject | HYPOXIA | - |
dc.subject | LIGNAN | - |
dc.title | Arctigenin protects against ultraviolet-A-induced damage to stemness through inhibition of the NF-kappa B/MAPK pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000425309100009 | - |
dc.identifier.doi | 10.1016/j.cbi.2018.01.005 | - |
dc.identifier.bibliographicCitation | CHEMICO-BIOLOGICAL INTERACTIONS, v.282, pp.63 - 68 | - |
dc.identifier.scopusid | 2-s2.0-85040702910 | - |
dc.citation.endPage | 68 | - |
dc.citation.startPage | 63 | - |
dc.citation.title | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.volume | 282 | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Arctigenin | - |
dc.subject.keywordAuthor | Human mesenchymal stem cells | - |
dc.subject.keywordAuthor | Stemness | - |
dc.subject.keywordAuthor | UVA damage | - |
dc.subject.keywordAuthor | HIF | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | LIGNAN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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