Temporal improvement in survival of patients with hepatocellular carcinoma in a hepatitis B virus-endemic population
DC Field | Value | Language |
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dc.contributor.author | Kim, Bo Hyun | - |
dc.contributor.author | Lim, Young-Suk | - |
dc.contributor.author | Kim, Eun-Yang | - |
dc.contributor.author | Kong, Hyun-Joo | - |
dc.contributor.author | Won, Young-Joo | - |
dc.contributor.author | Han, Seungbong | - |
dc.contributor.author | Park, Sohee | - |
dc.contributor.author | Hwang, Jae Seok | - |
dc.date.available | 2020-02-27T11:42:23Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4068 | - |
dc.description.abstract | Background and Aim: Over the past decade, the management of hepatocellular carcinoma (HCC) and viral hepatitis has been improved. We explored survival trends and factors affecting survival of HCC in a hepatitis B virus (HBV)-endemic population. Methods: From 31521 and 38167 HCC registrants to the population-based national cancer registry in Korea, an HBV-endemic country, in the period of 2003-2005 and 2008-2010, we randomly sampled cohorts of 4515 and 4582 patients, respectively, for the investigation of clinical characteristics and survival. Results: Compared with Cohort 2003-2005, Cohort 2008-2010 had significantly better liver function (Child-Turcotte-Pugh class A, 64.2% vs 71.6%; P < 0.001) and had more advanced tumor stages (Barcelona Clinic Liver Cancer stage B-D, 45.8% vs 50.4%; P < 0.001). HBV was the predominant cause of HCC in both cohorts (62.5% vs 62.2%; P = 0.70). Cohort 2008-2010 had significantly better overall survival than Cohort 2003-2005 by age-adjusted univariate, multivariable, and propensity score-matched analyses (median survival time, 17.2 vs 28.4 months; P < 0.001). In a subcohort analysis, a consistently significant inter-cohort improvement in survival was observed only in patients with HBV-related HCC (median survival, 16.1 vs 30.4 months; P < 0.001). The annual number of patients with HCC receiving oral antiviral agents for HBV precipitously increased from 93 in 2005 to 28520 in 2010 in the country. Conclusions: The consistent improvement in survival of patients with HCC was confined to HBV-related HCC subcohort over the last decade in an HBV-endemic population. The survival improvement coincided with the exponential use of oral antiviral agents for HBV in the patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.subject | TUMOR RECURRENCE | - |
dc.subject | CANCER | - |
dc.subject | ANALOGS | - |
dc.subject | ASSOCIATION | - |
dc.subject | MANAGEMENT | - |
dc.subject | INCREASES | - |
dc.subject | KOREA | - |
dc.subject | RISK | - |
dc.title | Temporal improvement in survival of patients with hepatocellular carcinoma in a hepatitis B virus-endemic population | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000423412900024 | - |
dc.identifier.doi | 10.1111/jgh.13848 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.33, no.2, pp.475 - 483 | - |
dc.identifier.scopusid | 2-s2.0-85041031387 | - |
dc.citation.endPage | 483 | - |
dc.citation.startPage | 475 | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Han, Seungbong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hepatitis B virus | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | population | - |
dc.subject.keywordAuthor | registry | - |
dc.subject.keywordPlus | TUMOR RECURRENCE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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