Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Soo | - |
dc.contributor.author | Lee, Sangmin | - |
dc.contributor.author | Yun, Sanguk | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Park, Jongmi | - |
dc.contributor.author | Cui, Minghua | - |
dc.contributor.author | Choi, Sun | - |
dc.contributor.author | Cha, Sun-Shin | - |
dc.contributor.author | Jin, Wook | - |
dc.date.available | 2020-02-27T11:42:25Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4074 | - |
dc.description.abstract | The DJ-1 protein engages in diverse cellular and pathological processes, including tumorigenesis, apoptosis, sperm fertilization, and the progression of Parkinson's disease (PD). The functional dimeric form of DJ-1 transforms into non-functional filamentous aggregates in an inorganic phosphate (P-1)-dependent manner in vitro. Here, we demonstrated that P-i and reactive oxygen species (ROS) induce DJ-1 aggregation in Neuro2A and SH-SY5Y cells. Remarkably, tartrate treatment significantly reduced P-i- and ROS-induced DJ-1 aggregation and restored P-i- and ROS-provoked cell death using quantitative data as mean +/- standard deviation, and statistics. Mechanistically, tartrate prevented DJ-1 aggregation via occupying the P-i-binding site. These findings revealed an unexpected physiological role of tartrate in the maintenance of DJ-1 function, and thus, a potential use as an inhibitor of DJ-1 aggregation. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.subject | FAMILIAL PARKINSONS-DISEASE | - |
dc.subject | EARLY-ONSET PARKINSONISM | - |
dc.subject | MULTIPLE SYSTEM ATROPHY | - |
dc.subject | CHRONIC KIDNEY-DISEASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | ALPHA-SYNUCLEIN | - |
dc.subject | PROTEIN DJ-1 | - |
dc.subject | IN-VIVO | - |
dc.subject | VASCULAR CALCIFICATION | - |
dc.subject | PHOSPHORUS-METABOLISM | - |
dc.title | Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000424062300032 | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2017.10.022 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.107, pp.1650 - 1658 | - |
dc.identifier.scopusid | 2-s2.0-85031501683 | - |
dc.citation.endPage | 1658 | - |
dc.citation.startPage | 1650 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.citation.volume | 107 | - |
dc.contributor.affiliatedAuthor | Kim, Min Soo | - |
dc.contributor.affiliatedAuthor | Jin, Wook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Tartrate | - |
dc.subject.keywordAuthor | DJ-1 | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Inorganic phosphate | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordPlus | FAMILIAL PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | EARLY-ONSET PARKINSONISM | - |
dc.subject.keywordPlus | MULTIPLE SYSTEM ATROPHY | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | PROTEIN DJ-1 | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | VASCULAR CALCIFICATION | - |
dc.subject.keywordPlus | PHOSPHORUS-METABOLISM | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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