Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders
- Authors
- Choi, Jin Gyu; Kim, Sun Yeou; Jeong, Minsun; Oh, Myung Sook
- Issue Date
- Feb-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Ginger; 6-gingerol; 6-shogaol; Zingerone; Age-related neurological disorders
- Citation
- PHARMACOLOGY & THERAPEUTICS, v.182, pp.56 - 69
- Journal Title
- PHARMACOLOGY & THERAPEUTICS
- Volume
- 182
- Start Page
- 56
- End Page
- 69
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4077
- DOI
- 10.1016/j.pharmthera.2017.08.010
- ISSN
- 0163-7258
- Abstract
- Age-related neurological disorders (ANDs), including neurodegenerative diseases, are multifactorial disorders with a risk that increases with aging. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Recently, efforts have been made to overcome ANDs because of the increase in age-dependent prevalence. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms. The structure-activity relationships of ginger phytochemicals show that ginger can be used to treat ANDs by targeting different ligand sites. This review shows that ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone, are effective for ameliorating the neurological symptoms and pathological conditions of ANDs through by modulating cell death or cell survival signaling molecules. From this review, we conclude that the active ingredients in ginger have therapeutic potential in ANDs.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4077)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.