Triphenylphosphine-docetaxel conjugate-incorporated albumin nanoparticles for cancer treatment
DC Field | Value | Language |
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dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Gotov, Oyuntuya | - |
dc.contributor.author | Kang, Jee He | - |
dc.contributor.author | Cho, Jinsung | - |
dc.contributor.author | Jeong, Tae Ho | - |
dc.contributor.author | Chimed, Ganzorig | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-27T11:42:36Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4098 | - |
dc.description.abstract | Aim: The objective of this study was to develop a mitochondria-targeted anticancer drug, docetaxel (DTX), for chemotherapy. Materials & methods: The DTX was conjugated to 4-carboxybutyl triphenylphosphonium (TPP) to enhance mitochondrial targeting, and the TPP-DTX conjugate was further loaded into folate-cholesteryl albumin (FA-chol-BSA) nanoparticles (NPs) to improve its biocompatibility. Results & conclusion: In vitro studies showed that TPP-DTX and its NP primarily accumulated in the mitochondria; generated high reactive oxygen species, leading to mitochondrial disruption and cell apoptosis; and had a higher cytotoxicity against cancer cells. In vivo antitumor studies indicated that the NP significantly suppressed tumor growth compared with free drugs in xenograft tumor-bearing mice. Our results demonstrated that TPP-DTX@FA-chol-BSA NPs could be a promising mitochondria-targeted anticancer prodrug for chemotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.relation.isPartOf | NANOMEDICINE | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | LUNG-CANCER | - |
dc.subject | IN-VITRO | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | PACLITAXEL | - |
dc.subject | TARGET | - |
dc.subject | LIPOSOMES | - |
dc.subject | APOPTOSIS | - |
dc.subject | TOXICITY | - |
dc.title | Triphenylphosphine-docetaxel conjugate-incorporated albumin nanoparticles for cancer treatment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000427393300007 | - |
dc.identifier.doi | 10.2217/nnm-2017-0274 | - |
dc.identifier.bibliographicCitation | NANOMEDICINE, v.13, no.3, pp.325 - 338 | - |
dc.identifier.scopusid | 2-s2.0-85041168851 | - |
dc.citation.endPage | 338 | - |
dc.citation.startPage | 325 | - |
dc.citation.title | NANOMEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Battogtokh, Gantumur | - |
dc.contributor.affiliatedAuthor | Gotov, Oyuntuya | - |
dc.contributor.affiliatedAuthor | Kang, Jee He | - |
dc.contributor.affiliatedAuthor | Cho, Jinsung | - |
dc.contributor.affiliatedAuthor | Jeong, Tae Ho | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | anticancer drug | - |
dc.subject.keywordAuthor | docetaxel | - |
dc.subject.keywordAuthor | mitochondria targeting | - |
dc.subject.keywordAuthor | self-assembled albumin nanoparticle | - |
dc.subject.keywordAuthor | triphenylphosphonium cation | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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