Prognostic significance of CT-determined emphysema in patients with small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee Young | - |
dc.contributor.author | Kim, Eun Young | - |
dc.contributor.author | Kim, Young Saing | - |
dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Kim, Yoon Kyung | - |
dc.date.available | 2020-02-27T11:42:36Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 2072-1439 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4099 | - |
dc.description.abstract | Background: Although emphysema and small cell lung cancer (SCLC) are prevalent in smokers, no previous study has investigated the prognostic impact of computed tomography (CT)-determined emphysema in SCLC. This study was undertaken to analyze the prognostic value of emphysema scores as determined by baseline CT scans in patients with SCLC. Methods: The data of 149 consecutive patients with SCLC were analyzed. Emphysema severity was semi-quantitatively scored on baseline chest CT images using the Goddard scoring system (possible scores for individual patients ranged from 0 to 24). Data on clinical characteristics and survival were retrospectively collected. Survivals were estimated using the Kaplan-Meier method and compared using the log-rank test. A multivariable Cox proportional hazard model was used to identify prognostic factors. Results: Most of the 149 patients were male (85.2%) and current/ex-smokers (87.2%). The median CT emphysema score was 4 (range, 0 to 23). Univariable analysis, patients with a higher CT emphysema score (>= 8) had significantly poorer overall survivals (OS) than those with lower scores (5.0 vs. 12.3 months, P<0.001). Multivariable analysis showed a higher CT emphysema score (treated as a continuous variable) was a significant independent prognostic factor of poor survival [hazard ratio (HR), 1.85; 95% confidence interval (CI), 1.14 to 3.00; P=0.012], along with extensive stage (HR, 2.27; 95% CI, 1.45-3.53; P<0.001), elevated lactate dehydrogenase (LDH) (HR, 1.52; 95% CI, 1.03-2.23; P=0.034), and supportive care only (HR, 6.46; 95% CI, 3.64-11.48; P<0.001). Conclusions: Emphysema severity, as determined by baseline CT, is significantly associated with poor prognosis in SCLC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AME PUBL CO | - |
dc.relation.isPartOf | JOURNAL OF THORACIC DISEASE | - |
dc.subject | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject | COMPUTED-TOMOGRAPHY | - |
dc.subject | AIRWAY-OBSTRUCTION | - |
dc.subject | COPD | - |
dc.subject | METAANALYSIS | - |
dc.subject | INHIBITORS | - |
dc.subject | SCORES | - |
dc.subject | IMPACT | - |
dc.title | Prognostic significance of CT-determined emphysema in patients with small cell lung cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000427737200086 | - |
dc.identifier.doi | 10.21037/jtd.2018.01.97 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC DISEASE, v.10, no.2, pp.874 - 881 | - |
dc.identifier.scopusid | 2-s2.0-85042117492 | - |
dc.citation.endPage | 881 | - |
dc.citation.startPage | 874 | - |
dc.citation.title | JOURNAL OF THORACIC DISEASE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Lee, Hee Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.contributor.affiliatedAuthor | Kim, Young Saing | - |
dc.contributor.affiliatedAuthor | Ahn, Hee Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Kyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | CT-emphysema score | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | small cell lung cancer (SCLC) | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | AIRWAY-OBSTRUCTION | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | SCORES | - |
dc.subject.keywordPlus | IMPACT | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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