Unblinded, randomized multicenter trial comparing lamotrigine and valproate combination with controlled-release carbamazepine monotherapy as initial drug regimen in untreated epilepsy
DC Field | Value | Language |
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dc.contributor.author | Lee, Byung In | - |
dc.contributor.author | No, Soon Kee | - |
dc.contributor.author | Yi, Sang-Doe | - |
dc.contributor.author | Lee, Hyang Woon | - |
dc.contributor.author | Kim, Ok Joon | - |
dc.contributor.author | Kim, Sang Ho | - |
dc.contributor.author | Kim, Myeong Kyu | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Kim, Yo Sik | - |
dc.contributor.author | Kim, Jae Moon | - |
dc.contributor.author | Lee, Se-Jin | - |
dc.contributor.author | Shin, Dong Jin | - |
dc.contributor.author | Park, Sung Pa | - |
dc.contributor.author | Kim, Yeong In | - |
dc.contributor.author | Heo, Kyoung | - |
dc.contributor.author | Cho, Yong Won | - |
dc.contributor.author | Cho, Yang-Je | - |
dc.contributor.author | Kim, Youn Nam | - |
dc.date.available | 2020-02-27T11:42:45Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1059-1311 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4115 | - |
dc.description.abstract | Purpose: To compare controlled-release carbamazepine monotherapy (CBZ-CR) with lamotrigine and valproate combination therapy (LTG + VPA) in equivalent total drug load, as initial drug regimen in untreated patients with partial and/or generalized tonic-clonic seizures (GTCS). Methods: This unblinded, randomized, 60-week superiority trial recruited patients having two or more unprovoked seizures with at least one seizure during previous three months. After randomization into CBZ-CR or LTG + VPA, patients entered into eight-week titration phase (TP), followed by 52-week maintenance phase (MP). Median doses of CBZ-CR and LTG + VPA were 600 mg/day and 75 mg/day, + 500 mg/day, respectively. Primary outcome measure was completion rate (CR), a proportion of patients who have completed the 60-week study as planned. Secondary efficacy measures included seizure-free rate (SFR) for 52-week of MP and time to first seizure (TTFS) during MP. Results: Among 207 randomized patients, 202 underwent outcome analysis (104 in CBZ-CR, 98 in LTG + VPA). CR was 62.5% in CBZ-CR and 65.3% in LTG + VPA (p = 0.678). SFR during MP was higher in LTG + VPA (64.1%) than CBZ-CR (47.8%) (P = 0.034). TTFS was shorter with CBZ-CR (p = 0.041). Incidence of adverse effects (AEs) were 57.7% in CBZ-CR and 60.2% in LTG + VPA and premature drug withdrawal rates due to AEs were 12.5% and 7.1%, respectively, which were not significantly different. Conclusion: CR was comparable between LTG + VPA and CBZ-CR, however, both SFR for 52-week MP and TTFS during MP were in favor of LTG + VPA than CBZ-CR. The study suggested that LTG + VPA can be an option as initial drug regimen for untreated patients with partial seizures and/or GTCS except for women of reproductive age. (C) 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO LTD | - |
dc.relation.isPartOf | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | - |
dc.subject | ANTIEPILEPTIC DRUGS | - |
dc.subject | ADJUNCTIVE THERAPY | - |
dc.subject | POLYTHERAPY | - |
dc.subject | EFFICACY | - |
dc.subject | SUBSTITUTION | - |
dc.subject | PREGNANCY | - |
dc.subject | SEIZURES | - |
dc.subject | PLACE | - |
dc.subject | WOMEN | - |
dc.subject | RASH | - |
dc.title | Unblinded, randomized multicenter trial comparing lamotrigine and valproate combination with controlled-release carbamazepine monotherapy as initial drug regimen in untreated epilepsy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000430644800004 | - |
dc.identifier.doi | 10.1016/j.seizure.2017.12.008 | - |
dc.identifier.bibliographicCitation | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, v.55, pp.17 - 24 | - |
dc.identifier.scopusid | 2-s2.0-85043358392 | - |
dc.citation.endPage | 24 | - |
dc.citation.startPage | 17 | - |
dc.citation.title | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | - |
dc.citation.volume | 55 | - |
dc.contributor.affiliatedAuthor | Shin, Dong Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Monotherapy | - |
dc.subject.keywordAuthor | Combination therapy | - |
dc.subject.keywordAuthor | CBZ-CR | - |
dc.subject.keywordAuthor | LTG plus VPA | - |
dc.subject.keywordAuthor | Initial drug regimen | - |
dc.subject.keywordPlus | ANTIEPILEPTIC DRUGS | - |
dc.subject.keywordPlus | ADJUNCTIVE THERAPY | - |
dc.subject.keywordPlus | POLYTHERAPY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SUBSTITUTION | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | SEIZURES | - |
dc.subject.keywordPlus | PLACE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | RASH | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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