Chemical characterization of cytotoxic indole acetic acid derivative from mulberry fruit (Morus alba L.) against human cervical cancer
DC Field | Value | Language |
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dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Choi, Chang-Ik | - |
dc.contributor.author | Jang, Tae Su | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-27T12:40:59Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4137 | - |
dc.description.abstract | The fruit of the white mulberry tree (Morus alba L.) is a multiple fruit with a sweet flavor commonly consumed around the world. Chemical investigation of the fruits led to the isolation of two indole acetic acid derivatives (1-2) including a new compound, which turned out to be an isolation artifact, 3S-(beta-D-gluco pyranosyloxy)-2,3-dihydro-2-oxo-1H-indole-3-acetic acid butyl ester (1), along with five known compounds (3-7). Compounds 2 and 7 were newly identified from mulberry fruit. The new isolation artifact (1) exhibited cytotoxic effect on human cervical cancer Hela cells in a dose-dependent manner. Compound 1 activated caspase-8, caspase-9, and caspase-3, followed by cleavage of PARP, a substrate of caspase-3, in a dose-dependent manner. Simultaneous alterations in protein expression of mitochondrial factors Bax, BID and Bcl-2 were also observed. A comparison between compounds 1 and 2 led to a structure-activity relationship analysis of the cytotoxic effect. These results suggest that compound 1 could be beneficial in human cervical cancer treatment, and provide a theoretical basis for further application of compound 1. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOORGANIC CHEMISTRY | - |
dc.subject | APOPTOSIS INDUCTION | - |
dc.subject | CISPLATIN | - |
dc.subject | ACCUMULATION | - |
dc.subject | ACTIVATION | - |
dc.subject | RESISTANCE | - |
dc.subject | CASPASE-3 | - |
dc.subject | DESIGN | - |
dc.subject | LEAVES | - |
dc.subject | CELLS | - |
dc.subject | BCL-2 | - |
dc.title | Chemical characterization of cytotoxic indole acetic acid derivative from mulberry fruit (Morus alba L.) against human cervical cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000425897800004 | - |
dc.identifier.doi | 10.1016/j.bioorg.2017.10.015 | - |
dc.identifier.bibliographicCitation | BIOORGANIC CHEMISTRY, v.76, pp.28 - 36 | - |
dc.identifier.scopusid | 2-s2.0-85032796899 | - |
dc.citation.endPage | 36 | - |
dc.citation.startPage | 28 | - |
dc.citation.title | BIOORGANIC CHEMISTRY | - |
dc.citation.volume | 76 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Mulberry | - |
dc.subject.keywordAuthor | Morus alba | - |
dc.subject.keywordAuthor | Indole acetic acid | - |
dc.subject.keywordAuthor | Human cervical cancer | - |
dc.subject.keywordPlus | APOPTOSIS INDUCTION | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CASPASE-3 | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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