Transcriptomic and histopathological analysis of cholangiolocellular differentiation trait in intrahepatic cholangiocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rhee, Hyungjin | - |
dc.contributor.author | Ko, Jung Eun | - |
dc.contributor.author | Chung, Taek | - |
dc.contributor.author | Jee, Byul A. | - |
dc.contributor.author | Kwon, So Mee | - |
dc.contributor.author | Nahm, Ji Hae | - |
dc.contributor.author | Seok, Jae Yeon | - |
dc.contributor.author | Yoo, Jeong Eun | - |
dc.contributor.author | Choi, Jin-Sub | - |
dc.contributor.author | Thorgeirsson, Snorri S. | - |
dc.contributor.author | Andersen, Jesper B. | - |
dc.contributor.author | Lee, Hye Sun | - |
dc.contributor.author | Woo, Hyun Goo | - |
dc.contributor.author | Park, Young Nyun | - |
dc.date.available | 2020-02-27T12:42:08Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4232 | - |
dc.description.abstract | Background & AimsIntrahepatic cholangiocarcinoma (iCCA) is a heterogeneous entity with diverse aetiologies, morphologies and clinical outcomes. Recently, histopathological distinction of cholangiolocellular differentiation (CD) of iCCA has been suggested. However, its genome-wide molecular features and clinical significance remain unclear. MethodsBased on CD status, we stratified iCCAs into iCCA with CD (n=20) and iCCA without CD (n=102), and performed an integrative analysis using transcriptomic and clinicopathological profiles. ResultsiCCA with CD revealed less aggressive histopathological features compared to iCCA without CD, and iCCA with CD showed favourable clinical outcomes of overall survival and time to recurrence than iCCA without CD (P<.05 for all). Transcriptomic profiling revealed that iCCA with CD resembled an inflammation-related subtype, while iCCA without CD resembled a proliferation subtype. In addition, we identified a CD signature that can predict prognostic outcomes of iCCA (CD_UP, n=486 and CD_DOWN, n=308). iCCAs were subgrouped into G1 (positivity for CRP and CDH2, 7%), G3 (positivity for S100P and TFF1, 32%) and G2 (the others, 61%). Prognostic outcomes for overall survival (P=.001) and time to recurrence (P=.017) were the most favourable in G1-iCCAs, intermediate in G2-iCCAs and the worst in G3-iCCAs. Similar result was confirmed in the iCCA set from GSE26566 (n=68). ConclusionsCD signature was identified to predict the prognosis of iCCA. The combined evaluation of histology of CD and protein expression status of CRP, CDH2, TFF1 and S100P might help subtyping and predicting clinical outcomes of iCCA. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.subject | PANCREATIC DUCTAL ADENOCARCINOMA | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | EXPRESSION | - |
dc.subject | TUMORS | - |
dc.subject | FEATURES | - |
dc.title | Transcriptomic and histopathological analysis of cholangiolocellular differentiation trait in intrahepatic cholangiocarcinoma | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000418724800014 | - |
dc.identifier.doi | 10.1111/liv.13492 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, v.38, no.1, pp.113 - 124 | - |
dc.identifier.scopusid | 2-s2.0-85022326727 | - |
dc.citation.endPage | 124 | - |
dc.citation.startPage | 113 | - |
dc.citation.title | LIVER INTERNATIONAL | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Seok, Jae Yeon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | CDH2 | - |
dc.subject.keywordAuthor | cholangiolocellular differentiation | - |
dc.subject.keywordAuthor | CRP | - |
dc.subject.keywordAuthor | S100P | - |
dc.subject.keywordAuthor | TFF1 | - |
dc.subject.keywordPlus | PANCREATIC DUCTAL ADENOCARCINOMA | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | FEATURES | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.