Diagnosis of Early-Stage Idiopathic Parkinson's Disease Using High-Resolution Quantitative Susceptibility Mapping Combined with Histogram Analysis in the Substantia Nigra at 3 T
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eung Yeop | - |
dc.contributor.author | Sung, Young Hee | - |
dc.contributor.author | Shin, Hyeong-Geol | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Nam, Yoonho | - |
dc.contributor.author | Lee, Jongho | - |
dc.date.available | 2020-02-27T12:42:17Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4242 | - |
dc.description.abstract | Background and Purpose To test whether nigrosome-1 imaging using high-resolution quantitative susceptibility mapping (QSM) combined with histogram analysis can improve the diagnostic accuracy in early-stage idiopathic Parkinson's disease (IPD) patients. Methods Three-dimensional multiecho gradient-recalled echo images (0.5x0.5x1.0 mm(3)) were obtained at 3 T for QSM in 38 patients with IPD and 25 healthy subjects. To segment the substantia nigra (SN), regions of interest (ROIs) were semiautomatically drawn at the location below the red nucleus, and the normal-appearing nigrosome-1 was determined by manual correction. QSM histograms were obtained within the ROI. The segmented SN regions on the right and left that had higher mean susceptibility values and fewer voxels with susceptibility values lower than 60, 65, 70, 75, and 80 ppb were chosen for comparisons between the IPD patients and healthy subjects. These results were compared with those of the visual assessments of nigrosome-1 in susceptibility map-weighted imaging (SMWI) by analyzing receiver operating characteristics curves. Results The proportion of voxels with susceptibility values lower than 70 ppb showed the best diagnostic performance, with its value differing significantly between the IPD patients (median=0, interquartile range=0-0.23) and healthy subjects (median=10.67, interquartile range=5.98-21.57) (p<0.0001). The number of voxels with susceptibility values lower than 60, 65, 70, 75, and 80 ppb showed worse diagnostic performances but were still significantly better than that of the mean susceptibility value (p=0.0249, 0.0192, 0.0183, 0.0191, and 0.0186, respectively), which also differed significantly between the two groups: 125.81 +/- 16.27 ppb (mean standard deviation) in IPD versus 98.41 +/- 11.70 ppb in healthy subjects (p<0.0001). Additionally, using the proportion of voxels with susceptibility values lower than 70 ppb provided significantly better diagnostic performance than did visual assessments of SMWI (p=0.0143). Conclusions High-spatial-resolution QSM combined with histogram analysis at 3 T can improve the diagnostic accuracy of early-stage IPD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.subject | SWALLOW-TAIL SIGN | - |
dc.subject | NIGROSOME 1 | - |
dc.subject | IRON DEPOSITION | - |
dc.subject | HUMAN BRAIN | - |
dc.subject | HYPERINTENSITY | - |
dc.subject | DISTINGUISH | - |
dc.subject | ASYMMETRY | - |
dc.subject | ACCURACY | - |
dc.subject | MRI | - |
dc.title | Diagnosis of Early-Stage Idiopathic Parkinson's Disease Using High-Resolution Quantitative Susceptibility Mapping Combined with Histogram Analysis in the Substantia Nigra at 3 T | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000419750300013 | - |
dc.identifier.doi | 10.3988/jcn.2018.14.1.90 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, v.14, no.1, pp.90 - 97 | - |
dc.identifier.kciid | ART002300904 | - |
dc.identifier.scopusid | 2-s2.0-85040686804 | - |
dc.citation.endPage | 97 | - |
dc.citation.startPage | 90 | - |
dc.citation.title | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.contributor.affiliatedAuthor | Sung, Young Hee | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | substantia nigra | - |
dc.subject.keywordAuthor | pars compacta | - |
dc.subject.keywordAuthor | ROC curve | - |
dc.subject.keywordPlus | SWALLOW-TAIL SIGN | - |
dc.subject.keywordPlus | NIGROSOME 1 | - |
dc.subject.keywordPlus | IRON DEPOSITION | - |
dc.subject.keywordPlus | HUMAN BRAIN | - |
dc.subject.keywordPlus | HYPERINTENSITY | - |
dc.subject.keywordPlus | DISTINGUISH | - |
dc.subject.keywordPlus | ASYMMETRY | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | MRI | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.