Cardiac structural or functional changes associated with CHA2DS2-VASc scores in nonvalvular atrial fibrillation: A cross-sectional study using echocardiography
DC Field | Value | Language |
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dc.contributor.author | Jang, A.Y. | - |
dc.contributor.author | Yu, J. | - |
dc.contributor.author | Park, Y.M. | - |
dc.contributor.author | Shin, M.S. | - |
dc.contributor.author | Chung, W.-J. | - |
dc.contributor.author | Moon, J. | - |
dc.date.available | 2020-02-27T12:43:56Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2586-7210 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4390 | - |
dc.description.abstract | BACKGROUND: CHA2DS2-VASc is the most widely accepted scoring system for atrial fibrillation (AF) to assess stroke risk, although little has been revealed regarding the accompanying cardiac functional/structural changes. This echocardiography study was undertaken to understand the changes related to CHA2DS2-VASc scores. METHODS: A total of 4,795 nonvalvular AF patients were enrolled for the cohort, from which 591 were excluded as they did not meet the inclusion criteria. Based on the CHA2DS2-VASc scores, the remaining 4,204 patients included in the study were divided into 4 groups: 0 to 1 (n = 991); 2 to 3 (n = 1,642); 4 to 6 (n = 1,407); 7 to 9 (n = 164). RESULTS: Increase in the left ventricular mass index and prevalence of left ventricular hypertrophy (LVH) were observed with elevating CHA2DS2-VASc scores (p < 0.05 for all). Diastolic parameters such as left atrial volume index (LAVI) and the ratio of early diastolic mitral inflow velocity to early diastolic velocity of the mitral annulus (E/E′) also increased significantly in the higher CHA2DS2-VASc score groups (p < 0.001 for all), although two-way ANOVA analysis showed that such incremental diastolic impairment was independent of hypertension. LVH (hazard ratio [HR], 3.609; confidence interval [CI], 2.426–5.369; p < 0.001) and E/E′ (HR, 1.087; CI, 1.054–1.121; p < 0.001) were independent risk factors for CHA2DS2-VASc scores 2 or higher. CONCLUSIONS: Our findings suggest that increasing CHA2DS2-VASc scores are associated with impaired diastolic function that may represent high left atrial pressure favoring thrombogenic propensity. © 2018 Korean Society of Echocardiography. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Echocardiography | - |
dc.relation.isPartOf | Journal of Cardiovascular Imaging | - |
dc.title | Cardiac structural or functional changes associated with CHA2DS2-VASc scores in nonvalvular atrial fibrillation: A cross-sectional study using echocardiography | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.4250/jcvi.2018.26.e17 | - |
dc.identifier.bibliographicCitation | Journal of Cardiovascular Imaging, v.26, no.3, pp.135 - 143 | - |
dc.identifier.kciid | ART002386046 | - |
dc.identifier.scopusid | 2-s2.0-85054406886 | - |
dc.citation.endPage | 143 | - |
dc.citation.startPage | 135 | - |
dc.citation.title | Journal of Cardiovascular Imaging | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Jang, A.Y. | - |
dc.contributor.affiliatedAuthor | Yu, J. | - |
dc.contributor.affiliatedAuthor | Park, Y.M. | - |
dc.contributor.affiliatedAuthor | Shin, M.S. | - |
dc.contributor.affiliatedAuthor | Chung, W.-J. | - |
dc.contributor.affiliatedAuthor | Moon, J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Cha2ds2-vasc score | - |
dc.subject.keywordAuthor | Diastolic dysfunction | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Left ventricular hypertrophy | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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