A New Diarylheptanoid from the Twigs of Quercus Acutissima and their Neuroprotective Activity

Abstract

A new diarylheptanoid glycoside, acutissioside A (4), along with five known diarylheptanoids (1-3, 5, 6) was isolated from the twigs of Quercus acutissima Carruth. The structure of the new compound was determined via spectral analysis, including NMR spectra (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, HMBC) and HR-ESI-MS, acid hydrolysis, and specific optical rotation data. The neuroprotective effect of all the diarylheptanoid compounds (1-6) was evaluated. Compound 1 exhibited NGF secretion to 154.60 +/- 2.87%, which was stronger than that of the positive control 6-shogaol (140.45 +/- 2.18%).